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TitleDesign and validation of a biomechanical bioreactor for cartilage tissue culture
Author(s)Correia, V.
Panadero, J. A.
Ribeiro, Clarisse Marta Oliveira
Sencadas, V.
Rocha, J. G.
Gomez Ribelles, J. L.
Lanceros-Méndez, S.
Mechanical stimulation
Cell culture
Issue date2016
PublisherSpringer Verlag
JournalBiomechanics and Modeling in Mechanobiology
CitationCorreia, V., Panadero, J. A., Ribeiro, C., Sencadas, V., Rocha, J. G., Gomez Ribelles, J. L., & Lanceros-Mendez, S. (2016). Design and validation of a biomechanical bioreactor for cartilage tissue culture. Biomechanics and Modeling in Mechanobiology, 15(2), 471-478. doi: 10.1007/s10237-015-0698-5
Abstract(s)Specific tissues, such as cartilage undergo mechanical solicitation under their normal performance in human body. In this sense, it seems necessary that proper tissue engineering strategies of these tissues should incorporate mechanical solicitations during cell culture, in order to properly evaluate the influence of the mechanical stimulus. This work reports on a user-friendly bioreactor suitable for applying controlled mechanical stimulation - amplitude and frequency - to three dimensional scaffolds. Its design and main components are described, as well as its operation characteristics. The modular design allows easy cleaning and operating under laminar hood. Different protocols for the sterilization of the hermetic enclosure are tested and ensure lack of observable contaminations, complying with the requirements to be used for cell culture. The cell viability study was performed with KUM5 cells.
AccessRestricted access (UMinho)
Appears in Collections:CAlg - Artigos em revistas internacionais/Papers in international journals
CDF - FCD - Artigos/Papers (with refereeing)

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