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|Title:||Poly(vinylidene fluoride-trifluoroethylene)/NAY zeolite hybrid membranes as a drug release platform applied to ibuprofen release|
Lima, A. C.
Lopes, A. C.
|Journal:||Colloids and Surfaces A: Physicochemical and Engineering Aspects|
|Citation:||Salazar, H., Lima, A. C., Lopes, A. C., Botelho, G., & Lanceros-Mendez, S. (2015). Poly(vinylidene fluoride-trifluoroethylene)/NAY zeolite hybrid membranes as a drug release platform applied to ibuprofen release. Colloids and Surfaces a-Physicochemical and Engineering Aspects, 469, 93-99. doi: 10.1016/j.colsurfa.2014.12.064|
|Abstract(s):||Poly(vinylidene fluoride-trifluoroethylene)/NaY zeolite composite membranes were prepared by solvent casting and evaluated as a suitable drug release platform through the evaluation of loading and release of ibuprofen. The membranes were characterized at the morphological, structural and mechanical levels. The 1H-NMR spectra indicate that only the membranes with 16 and 32 % of NaY were useful for IBU encapsulation and the drug release was followed by UV-Vis spectroscopy. The release profile is independent of the zeolite content and can be described by the Korsmeyer-Peppas model. The membrane with 32 % zeolite content releases more than double IBU amount when compared with the membrane with 16 % showing that zeolite content allows tailoring membrane drug release content for specific applications. The drug release platform developed in this work is suitable for other drugs and applications.|
|Access:||Restricted access (UMinho)|
|Appears in Collections:||CDF - FCD - Artigos/Papers (with refereeing)|
CDQuim - Artigos (Papers)
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