Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/38635

TítuloEpidermis recreation in spongy-like hydrogels: New opportunities to explore epidermis-like analogues
Autor(es)Cerqueira, M. T.
da Silva, L. P.
Correlo, V. M.
Reis, R. L.
Marques, A. P.
Palavras-chaveEpidermal analogues
Keratinocytes
DataOut-2015
EditoraElsevier
RevistaMaterials Today
CitaçãoCerqueira M. T., da Silva L. P., Correlo V. M., Reis R. L., Marques A. P. Epidermis recreation in spongy-like hydrogels: New opportunities to explore epidermis-like analogues, Materials Today, Vol. 18, Issue 8, pp. 468–469, doi:10.1016/j.mattod.2015.08.018, 2015
Resumo(s)[Excerpt] On the road to successfully achieving skin regeneration, 3D matrices/scaffolds that provide the adequate physico-chemical and biological cues to recreate the ideal healing environment are believed to be a key element [1], [2] and [3]. Numerous polymeric matrices derived from both natural [4] and [5] and synthetic [6], [7] and [8] sources have been used as cellular supports; nowadays, fewer matrices are simple carriers, and more and more are ECM analogues that can actively participate in the healing process. Therefore, the attractive characteristics of hydrogels, such as high water content, tunable elasticity and facilitated mass transportation, have made them excellent materials to mimic cells’ native environment [9]. Moreover, their hygroscopic nature [10] and possibility of attaining soft tissues-like mechanical properties mean they have potential for exploitation as wound healing promoters [11], [12], [13] and [14]. Nonetheless, hydrogels lack natural cell adhesion sites [15], which limits the maximization of their potential in the recreation of the cell niche. This issue has been tackled through the use of a range of sophisticated approaches to decorate the hydrogels with adhesion sequences such as arginine-glycine-aspartic acid (RGD) derived from fibronectin [16], [17] and [18], and tyrosine-isoleucine-glycine-serine-arginine (YIGSR) derived from laminin [18] and [19], which not only aim to modulate cell adhesion, but also influencing cell fate and survival [18]. Nonetheless, its widespread use is still limited by significant costs associated with the use of recombinant bioactive molecules.
Tipoarticle
URIhttp://hdl.handle.net/1822/38635
DOI10.1016/j.mattod.2015.08.018
ISSN1369-7021
Versão da editorahttp://www.sciencedirect.com/science/article/pii/S1369702115002692
Arbitragem científicayes
AcessoopenAccess
Aparece nas coleções:3B’s - Artigos em revistas/Papers in scientific journals

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