Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/38547

TitleBioactive nanocomposite spheres with proved shape memory capability in bone defects
Author(s)Leite, Álvaro J.
Caridade, S. G.
Mano, J. F.
KeywordsBioactive
Composites
Issue dateSep-2015
PublisherMary Ann Liebert
JournalTissue Engineering. Part A
CitationLeite A. J., Caridade S. G., Mano J. F. Bioactive Nanocomposite Spheres with Proved Shape Memory Capability in Bone Defects, Tissue Engineering Part A, Vol. 21, Issue S1, pp. S299-S299, doi:10.1089/ten.tea.2015.5000.abstracts., 2015
Abstract(s)Bioactive glass nanoparticles (BGNPs) promote an apatite surface layer in physiologic conditions that lead to a good interfacial bonding with bone.1 A strategy to induce bioactivity in non-bioactive polymeric biomaterials is to incorporate BGNPs in the polymer matrix. This combination creates a nanocomposite material with increased osteoconductive properties. Chitosan (CHT) is a polymer obtained by deacetylation of chitin and is biodegradable, non-toxic and biocompatible. The combination of CHT and the BGNPs aims at designing biocompatible spheres promoting the formation of a calcium phosphate layer at the nanocomposite surface, thus enhancing the osteoconductivity behaviour of the biomaterial. Shape memory polymers (SMP) are stimuli-responsive materials that offer mechanical and geometrical action triggered by an external stimulus.2 They can be deformed and fixed into a temporary shape which remains stable unless exposed to a proper stimulus that triggers recovery of their original shape. This advanced functionality makes such SMPs suitable to be implanted using minimally invasive surgery procedures. Regarding that, the inclusion of therapeutic molecules becomes attractive.  We propose the synthesis of shape memory bioactive nanocomposite spheres with drug release capability.3   1.  L. L. Hench, Am. Ceram. Soc. Bull., 1993, 72, 93-98. 2.  A. Lendlein and S. Kelch, Angew Chem Int Edit, 2002, 41, 2034-2057. 3.  Ã . J. Leite, S. G. Caridade and J. F. Mano, Journal of Non-Crystalline Solids (in Press)
TypeAbstract
URIhttp://hdl.handle.net/1822/38547
ISSN1937-3341
Publisher versionhttp://online.liebertpub.com/doi/full/10.1089/ten.tea.2015.5000.abstracts
Peer-Reviewedyes
AccessOpen access
Appears in Collections:3B’s - Resumos em livros de atas de conferências - indexados no ISI Web of Science

Files in This Item:
File Description SizeFormat 
18607-Poster 4th TERMIS World Congress - September 8-11, 2015.ppt.pdf4,67 MBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID