Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/38399

TítuloNanoparticle-based bioactive agent release systems for bone and cartilage tissue engineering
AutorMonteiro, Nelson
Martins, Albino
Reis, R. L.
Neves, N. M.
Palavras-chaveBioactive agents
Delivery systems
Mesenchymal stem cells
Nanoparticles
Scaffolds
DataJun-2015
EditoraElsevier
CitaçãoMonteiro N., Martins A., Reis R. L., Neves N. M. Nanoparticle-based bioactive agent release systems for bone and cartilage tissue engineering, Regenerative Therapy, Vol. 1, pp. 109–118, doi:doi:10.1016/j.reth.2015.05.004, 2015
ResumoThe inability to deliver bioactive agents locally in a transient but sustained manner is one of the challenges on the development of bio-functionalized scaffolds for tissue engineering (TE) and regenerative medicine. The mode of release is especially relevant when the bioactive agent is a growth factor (GF), because the dose and the spatiotemporal release of such agents at the site of injury are crucial to achieve a successful outcome. Strategies that combine scaffolds and drug delivery systems have the potential to provide more effective tissue regeneration relative to current therapies. Nanoparticles (NPs) can protect the bioactive agents, control its profile, decrease the occurrence and severity of side effects and deliver the bioactive agent to the target cells maximizing its effect. Scaffolds containing NPs loaded with bioactive agents can be used for their local delivery, enabling site-specific pharmacological effects such as the induction of cell proliferation and differentiation, and, consequently, neo-tissue formation. This review aims to describe the concept of combining NPs with scaffolds, and the current efforts aiming to develop highly multi-functional bioactive agent release systems, with the emphasis on their application in TE of connective tissues.
Tipoarticle
URIhttp://hdl.handle.net/1822/38399
DOI10.1016/j.reth.2015.05.004
ISSN2352-3204
Versão da editorahttp://www.sciencedirect.com/science/article/pii/S235232041500019X
Arbitragem científicayes
AcessoopenAccess
Aparece nas coleções:3B’s - Artigos em revistas/Papers in scientific journals

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