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TitleSerum total and bone alkaline phosphatase levels and their correlation with serum minerals over the lifespan of sheep
Author(s)Sousa, Cristina P.
Azevedo, Jorge T.
Silva, Amélia M.
Viegas, Carlos A.
Reis, R. L.
Gomes, Manuela E.
Dias, Isabel R.
Bone alkaline phosphatase
Physiologic state
Total alkaline phosphatase
Issue date2014
PublisherAkadémiai Kiadó
JournalActa Veterinaria Hungarica
CitationSousa C. P., Azevedo J. T., Silva A. M., Viegas C. A., Reis R. L., Gomes M. E., Dias I. R. Serum total and bone alkaline phosphatase levels and their correlation with serum minerals over the lifespan of sheep. Acta Veterinaria Hungarica, Acta Veterinaria Hungarica, Vol. 62, Issue 2, pp. 205-214, doi:10.1556/AVet.2013.049, 2013
Abstract(s)This study aimed to assess serum total alkaline phosphatase (ALP) and its bone isoform (BALP) levels during the ageing and in different physiologic states of sheep, in order to expand the knowledge about the variation of these biomarkers over the sheep lifespan. Ninety female sheep were divided into nine groups of various ages and physiological states (dry, lactation and pregnancy). Serum ALP, BALP and mineral levels were determined by commercial immunoassay, molecular absorbance spectrophotometry and chemical luminescence for BALP determination. Serum ALP and BALP decreased as sheep aged, and no statistically significant differences were obtained between ewes in different physiologic states. The continuous decline of serum BALP concentration along the sheep lifespan, namely in mature and old sheep, is a sign of decreasing bone turnover associated with ageing. Serum calcium concentrations increased slightly until 2 years of age and then showed a tenuous but statistically significant decrease in mature sheep, while serum phosphorus maintained an uninterrupted decrease as sheep matured. The knowledge of serum values of bone biomarkers throughout the sheep lifespan may be useful in preclinical orthopaedic research studies and for animal science studies using sheep.
Publisher version
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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