Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/38380

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dc.contributor.authorRibeiro, V. P.por
dc.contributor.authorRibeiro, A. S.por
dc.contributor.authorSilva, C. J.por
dc.contributor.authorDurães, N. F.por
dc.contributor.authorBonifácio, G.por
dc.contributor.authorCorrelo, V. M.por
dc.contributor.authorMarques, A. P.por
dc.contributor.authorSousa, R. A.por
dc.contributor.authorOliveira, A. L.por
dc.contributor.authorReis, R. L.por
dc.date.accessioned2015-11-23T17:42:15Z-
dc.date.available2015-11-23T17:42:15Z-
dc.date.issued2013-
dc.date.submitted2013-06-
dc.identifier.citationRibeiro V. P., Ribeiro A. S., Silva C. J., Durães N. F., Bonifácio G., Correlo V. M., Marques A. P., Sousa R. A., Oliveira A. L., Reis R. L. Evaluation of novel 3D architectures based on knitting technologies for engineering biological tissues, Journal of Donghua University (English Edition), Issue 5, pp. 421-426, 2013por
dc.identifier.issn1672-5220por
dc.identifier.urihttp://hdl.handle.net/1822/38380-
dc.description.abstractTextile-based technologies are considered as potential routes for the production of 3D porous architectures for tissue engineering applications. We describe the use of two polymers, namely polybutylene succinate (PBS) and silk fibroin (SF) to produce fiber-based finely tuned porous architectures by weft and warp knitting. The obtained knitted constructs are described in terms of their morphology, mechanical properties, swelling ability, degradation behaviour and cytotoxicity. Each type of polymer fibers allow for the processing of a very reproducible intra-architectural scaffold geometry, with distinct characteristics in terms of the surface physicochemistry, mechanical performance and degradation capability, which has an impact on the resulting cell behaviour at the surface of the respective biotextiles. Preliminary cytotoxicity screening shows that both materials can support cell adhesion and proliferation. Furthermore, different surface modifications were performed (acid/alkaline treatment, UV radiation and plasma) for modulating cell behavior. An increase of cell-material interactions were observed, indicating the important role of materials surface in the first hours of culturing. Human Adipose-derived Stem Cells (hASCs) became an emerging possibility for regenerative medicine and tissue replacement therapies. The potential of the recently developed silk-based biotextile structures to promote hASCs adhesion, proliferation and differentiation is also evaluated. The obtained results validate the developed constructs as viable matrices for TE applications. Given the processing efficacy and versatility of the knitting technology, and the interesting structural and surface properties of the proposed polymer fibers, it is foreseen that our developed systems can be attractive for the functional engineering of tissues such as bone, skin, ligaments or cartilage and also for develop more complex systems for further industrialization of TE products.por
dc.language.isoengpor
dc.publisherDonghua University (DHU)por
dc.rightsopenAccesspor
dc.subjectHuman adipose-derived stem cellspor
dc.subjectPBSpor
dc.subjectSilkpor
dc.subjectSurface modificationspor
dc.subjectTextile-based technologiespor
dc.subjectTissue engineeringpor
dc.subjectHuman adipose-derived stem cells (hASCs)por
dc.subjectPolybutylene succinate (PBS)por
dc.subjectTissue engineering (TE)por
dc.titleEvaluation of novel 3D architectures based on knitting technologies for engineering biological tissuespor
dc.typearticle-
dc.peerreviewedyespor
dc.relation.publisherversionhttp://caod.oriprobe.com/articles/42144906/Evaluation_of_Novel_3D_Architectures_Based_on_Knitting_Technologies_fo.htmpor
dc.commentshttp://www.3bs.uminho.pt/node/18128por
dc.publicationstatuspublishedpor
degois.publication.firstPage421por
degois.publication.lastPage426por
degois.publication.issue5por
degois.publication.titleJournal of Donghua University (English Edition)por
degois.publication.volume5por
dc.date.updated2015-11-09T16:06:03Z-
sdum.subject.fosDomínio/Área científica::Ciências Médicas::Biotecnologia Médicapor
sdum.journalJournal of Donghua University (english Edition)por
Aparece nas coleções:3B’s - Artigos em revistas/Papers in scientific journals

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