Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/38374

TitleNovel non-cytotoxic alginate–lignin hybrid aerogels as scaffolds for tissue engineering
Author(s)Quraishi, Sakeena
Martins, Marta
Barros, Alexandre A.
Gurikov, Pavel
Raman, S. P.
Smirnova, Irina
Duarte, Ana Rita C.
Reis, R. L.
KeywordsAlginate
Biomaterials
Lignin
Scaffolds
Supercritical
Tissue engineering
Issue dateOct-2015
PublisherElsevier
JournalThe Journal of Supercritical Fluids
CitationQuraishi S., Martins M., Barros A. A., Gurikova P., Raman S. P., Smirnova I., Duarte A. R. C., Reis R. L. Novel non-cytotoxic alginate–lignin hybrid aerogels as scaffolds for tissue engineering, The Journal of Supercritical Fluids, Vol. 105, pp. 1-8, doi:10.1016/j.supflu.2014.12.026, 2015
Abstract(s)This paper presents a novel approach towards the production of hybrid alginate-lignin aerogels. The key idea of the approach is to employ pressurized carbon dioxide for gelation. Exposure of alginate and lignin solution containing calcium carbonate to CO2 at 4.5 MPa resulted in a hydrogel formation. Various lignin and CaCO3 concentrations were studied. Stable hydrogels can be formed up to 2:1 (w/w) alginate-to-lignin ratio. Upon substitution of water with ethanol, gels were dried in supercritical CO2 to produce aerogels. Aerogels were characterized in terms of bulk density, specific surface area and pore volume. To introduce macroporosity, the CO2 induced gelation was supplemented with rapid depressurization (foaming process). Porosity, mean pore size and interconnectivity in the macroporous range were assessed by micro-CT. Youngâ s modulus of alginate-lignin aerogels was measured in both dry and wet state. Cell studies revealed that alginate-lignin aerogels are non-cytotoxic and demonstrate good cell adhesion properties making them attractive candidates for a wide range of applications including tissue engineering and regenerative medicine.
TypeArticle
Descriptionuncorrected proof
URIhttp://hdl.handle.net/1822/38374
DOI10.1016/j.supflu.2014.12.026
ISSN0896-8446
Publisher versionhttp://www.sciencedirect.com/science/article/pii/S0896844615000133
Peer-Reviewedyes
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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