Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/38309

TitleThe crosstalk between tissue engineering and pharmaceutical biotechnology: Recent advances and future directions
Author(s)Pacheco, Daniela P.
Reis, R. L.
Correlo, V. M.
Marques, A. P.
Keywords3D tissue-like models
Pharmaceutical biotechnology
Tissue engineering
Tissue-engineered constructs
Issue date2015
PublisherBentham Science Publishers
JournalCurrent Pharmaceutical Biotechnology
CitationPacheco D. P., Reis R. L., Correlo V. M., Marques A. P. The Crosstalk between Tissue Engineering and Pharmaceutical Biotechnology: Recent Advances and Future Directions, Advances in Pharmaceutical Biotechnology, Vol. 16, Issue 11, pp. 1012-1023, doi:10.2174/1389201016666150826120257#sthash.iRWcjU4u.dpuf, 2015
Abstract(s)Tissue-engineered constructs made of biotechnology-derived materials have been preferred due to their chemical and physical composition, which offers both high versatility and a support to enclose/incorporate relevant signaling molecules and/or genes known to therapeutically induce tissue repair. Herein, a critical overview of the impact of different biotechnology-derived materials, scaffolds, and recombinant signaling molecules over the behavior of cells, another element of tissue engineered constructs, as well its regulatory role in tissue regeneration and disease progression is given. Additionally, these tissue-engineered constructs evolved to three-dimensional (3D) tissue-like models that, as an advancement of two-dimensional standard culture methods, are expected to be a valuable tool in the field of drug discovery and pharmaceutical research. Despite the improved design and conception of current proposed 3D tissue-like models, advanced control systems to enable and accelerate streamlining and automation of the numerous labor-intensive steps intrinsic to the development of tissue-engineered constructs are still to be achieved. In this sense, this review intends to present the biotechnology-derived materials that are being explored in the field of tissue engineering to generate 3D tissue-analogues and briefly highlight their foremost breakthroughs in tissue regeneration and drug discovery. It also aims to reinforce that the crosstalk between tissue engineering and pharmaceutical biotechnology has been fostering the outcomes of tissue engineering approaches through the use of biotechnology-derived signaling molecules. Gene delivery/therapy is also discussed as a forefront area that represents another cross point between tissue engineering and pharmaceutical biotechnology, in which nucleic acids can be considered a â super pharmaceuticalâ to drive biological responses, including tissue regeneration. 
TypeArticle
URIhttp://hdl.handle.net/1822/38309
DOI10.2174/1389201016666150826120257
ISSN1389-2010
1873-4316
Publisher versionhttp://benthamscience.com/journals/current-pharmaceutical-biotechnology/volume/16/issue/11/page/1012/
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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