Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/38103
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Aroso, Ivo Manuel Ascensão | por |
dc.contributor.author | Craveiro, Rita | por |
dc.contributor.author | Rocha, Ângelo | por |
dc.contributor.author | Dionisio, Madalena | por |
dc.contributor.author | Barreiros, Susana | por |
dc.contributor.author | Reis, R. L. | por |
dc.contributor.author | Paiva, Alexandre | por |
dc.contributor.author | Duarte, Ana Rita C. | por |
dc.date.accessioned | 2015-11-11T11:59:11Z | - |
dc.date.available | 2015-11-11T11:59:11Z | - |
dc.date.issued | 2015-08 | - |
dc.date.submitted | 2015-03 | - |
dc.identifier.citation | Aroso I. M., Craveiro R., Rocha A., Dionisio M., Barreiros S., Reis R. L., Paiva A., Duarte A. R. C. Design of controlled release systems for THEDES - therapeutic deep eutectic solvents, using supercritical fluid technology, International Journal of Pharmaceutics, Vol. 492, Issue 1-2, pp. 73-79, doi:10.1016/j.ijpharm.2015.06.038, 2015 | por |
dc.identifier.issn | 0378-5173 | por |
dc.identifier.uri | https://hdl.handle.net/1822/38103 | - |
dc.description.abstract | Deep eutectic solvents (DES) can be formed by bioactive compounds or pharmaceutical ingredients. A therapeutic DES (THEDES) based on ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), and menthol was synthesized and its thermal behavior was analyzed by differential scanning calorimetry (DSC). A controlled drug delivery system was developed by impregnating a starch:poly-ϵ-caprolactone polymeric blend (SPCL 30:70) with the menthol:ibuprofen THEDES in different ratios (10 and 20 wt%), after supercritical fluid sintering at 20 MPa and 50 °C. The morphological characterization of SPCL matrices impregnated with THEDES was performed by scanning electron microscopy (SEM) and micro-computed tomography (micro-CT). Drug release studies were carried out in a phosphate buffered saline. The results obtained provide important clues for the development of carriers for the sustainable delivery of bioactive compounds. | por |
dc.description.sponsorship | Projects ENIGMA - PTDC/EQU-EPR/121491/2010, PTDC/QUI-QUI/119210/2010, PTDC/EQU-EQU/122106/2010, PEst-C/EQB/LA0006/2013 from the European Union’s Seventh Framework Programme (FP7/2007-2013) under grant agreement n° REGPOT - CT2012-316331-POLARIS and from Project “Novel smart and biomimetic materials for innovative regenerative medicine approaches (Ref.: RL1 - ABMR - NORTE-01-0124-FEDER-000016)” co-financed by North Portugal Regional Operational Programme (ON.2–O Novo Norte), under the National Strategic Reference Framework (NSRF), through the European Regional Development Fund (ERDF). | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier | por |
dc.relation | info:eu-repo/grantAgreement/FCT/5876-PPCDTI/121491/PT | - |
dc.relation | info:eu-repo/grantAgreement/FCT/COMPETE/121491/PT | - |
dc.relation | info:eu-repo/grantAgreement/FCT/3599-PPCDT/119210/PT | - |
dc.relation | info:eu-repo/grantAgreement/FCT/3599-PPCDT/122106/PT | - |
dc.relation | info:eu-repo/grantAgreement/FCT/COMPETE/132972/PT | - |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/316331/EU | - |
dc.rights | openAccess | por |
dc.subject | Biodegradable polymers | por |
dc.subject | Drug delivery systems | por |
dc.subject | Ibuprofen | por |
dc.subject | Supercritical carbon dioxide | por |
dc.subject | Therapeutic deep eutectic solvents | por |
dc.title | Design of controlled release systems for THEDES - therapeutic deep eutectic solvents, using supercritical fluid technology | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://www.sciencedirect.com/science/article/pii/S0378517315300053 | por |
dc.comments | http://www.3bs.uminho.pt/node/18473 | por |
sdum.publicationstatus | published | por |
oaire.citationStartPage | 73 | por |
oaire.citationEndPage | 79 | por |
oaire.citationIssue | 1-2 | por |
oaire.citationTitle | International Journal of Pharmaceutics | por |
oaire.citationVolume | 492 | por |
dc.date.updated | 2015-11-06T17:23:37Z | - |
dc.identifier.doi | 10.1016/j.ijpharm.2015.06.038 | por |
dc.identifier.pmid | 26142248 | por |
dc.subject.fos | Ciências Médicas::Biotecnologia Médica | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | International Journal of Pharmaceutics | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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18473-SPCL THEDES_Int J Pharm 2015.pdf | 1,46 MB | Adobe PDF | Ver/Abrir |