Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/38103

TítuloDesign of controlled release systems for THEDES - therapeutic deep eutectic solvents, using supercritical fluid technology
AutorAroso, Ivo Manuel Ascensão
Craveiro, Rita
Rocha, Ângelo
Dionisio, Madalena
Barreiros, Susana
Reis, R. L.
Paiva, Alexandre
Duarte, Ana Rita C.
Palavras-chaveBiodegradable polymers
Drug delivery systems
Ibuprofen
Supercritical carbon dioxide
Therapeutic deep eutectic solvents
DataAgo-2015
EditoraElsevier
CitaçãoAroso I. M., Craveiro R., Rocha A., Dionisio M., Barreiros S., Reis R. L., Paiva A., Duarte A. R. C. Design of controlled release systems for THEDES - therapeutic deep eutectic solvents, using supercritical fluid technology, International Journal of Pharmaceutics, Vol. 492, Issue 1-2, pp. 73-79, doi:10.1016/j.ijpharm.2015.06.038, 2015
ResumoDeep eutectic solvents (DES) can be formed by bioactive compounds or pharmaceutical ingredients. A therapeutic DES (THEDES) based on ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), and menthol was synthesized and its thermal behavior was analyzed by differential scanning calorimetry (DSC). A controlled drug delivery system was developed by impregnating a starch:poly-ϵ-caprolactone polymeric blend (SPCL 30:70) with the menthol:ibuprofen THEDES in different ratios (10 and 20 wt%), after supercritical fluid sintering at 20 MPa and 50 °C. The morphological characterization of SPCL matrices impregnated with THEDES was performed by scanning electron microscopy (SEM) and micro-computed tomography (micro-CT). Drug release studies were carried out in a phosphate buffered saline. The results obtained provide important clues for the development of carriers for the sustainable delivery of bioactive compounds.
Tipoarticle
URIhttp://hdl.handle.net/1822/38103
DOI10.1016/j.ijpharm.2015.06.038
ISSN0378-5173
Versão da editorahttp://www.sciencedirect.com/science/article/pii/S0378517315300053
Arbitragem científicayes
AcessoopenAccess
Aparece nas coleções:3B’s - Artigos em revistas/Papers in scientific journals

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