Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/38103

TítuloDesign of controlled release systems for THEDES - therapeutic deep eutectic solvents, using supercritical fluid technology
Autor(es)Aroso, Ivo Manuel Ascensão
Craveiro, Rita
Rocha, Ângelo
Dionisio, Madalena
Barreiros, Susana
Reis, R. L.
Paiva, Alexandre
Duarte, Ana Rita C.
Palavras-chaveBiodegradable polymers
Drug delivery systems
Supercritical carbon dioxide
Therapeutic deep eutectic solvents
RevistaInternational Journal of Pharmaceutics
CitaçãoAroso I. M., Craveiro R., Rocha A., Dionisio M., Barreiros S., Reis R. L., Paiva A., Duarte A. R. C. Design of controlled release systems for THEDES - therapeutic deep eutectic solvents, using supercritical fluid technology, International Journal of Pharmaceutics, Vol. 492, Issue 1-2, pp. 73-79, doi:10.1016/j.ijpharm.2015.06.038, 2015
Resumo(s)Deep eutectic solvents (DES) can be formed by bioactive compounds or pharmaceutical ingredients. A therapeutic DES (THEDES) based on ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), and menthol was synthesized and its thermal behavior was analyzed by differential scanning calorimetry (DSC). A controlled drug delivery system was developed by impregnating a starch:poly-ϵ-caprolactone polymeric blend (SPCL 30:70) with the menthol:ibuprofen THEDES in different ratios (10 and 20 wt%), after supercritical fluid sintering at 20 MPa and 50 °C. The morphological characterization of SPCL matrices impregnated with THEDES was performed by scanning electron microscopy (SEM) and micro-computed tomography (micro-CT). Drug release studies were carried out in a phosphate buffered saline. The results obtained provide important clues for the development of carriers for the sustainable delivery of bioactive compounds.
Versão da editorahttp://www.sciencedirect.com/science/article/pii/S0378517315300053
Arbitragem científicayes
Aparece nas coleções:3B’s - Artigos em revistas/Papers in scientific journals

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