Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/38103

TitleDesign of controlled release systems for THEDES - therapeutic deep eutectic solvents, using supercritical fluid technology
Author(s)Aroso, Ivo Manuel Ascensão
Craveiro, Rita
Rocha, Ângelo
Dionisio, Madalena
Barreiros, Susana
Reis, R. L.
Paiva, Alexandre
Duarte, Ana Rita C.
KeywordsBiodegradable polymers
Drug delivery systems
Ibuprofen
Supercritical carbon dioxide
Therapeutic deep eutectic solvents
Issue dateAug-2015
PublisherElsevier
JournalInternational Journal of Pharmaceutics
CitationAroso I. M., Craveiro R., Rocha A., Dionisio M., Barreiros S., Reis R. L., Paiva A., Duarte A. R. C. Design of controlled release systems for THEDES - therapeutic deep eutectic solvents, using supercritical fluid technology, International Journal of Pharmaceutics, Vol. 492, Issue 1-2, pp. 73-79, doi:10.1016/j.ijpharm.2015.06.038, 2015
Abstract(s)Deep eutectic solvents (DES) can be formed by bioactive compounds or pharmaceutical ingredients. A therapeutic DES (THEDES) based on ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), and menthol was synthesized and its thermal behavior was analyzed by differential scanning calorimetry (DSC). A controlled drug delivery system was developed by impregnating a starch:poly-ϵ-caprolactone polymeric blend (SPCL 30:70) with the menthol:ibuprofen THEDES in different ratios (10 and 20 wt%), after supercritical fluid sintering at 20 MPa and 50 °C. The morphological characterization of SPCL matrices impregnated with THEDES was performed by scanning electron microscopy (SEM) and micro-computed tomography (micro-CT). Drug release studies were carried out in a phosphate buffered saline. The results obtained provide important clues for the development of carriers for the sustainable delivery of bioactive compounds.
TypeArticle
URIhttp://hdl.handle.net/1822/38103
DOI10.1016/j.ijpharm.2015.06.038
ISSN0378-5173
Publisher versionhttp://www.sciencedirect.com/science/article/pii/S0378517315300053
Peer-Reviewedyes
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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