Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/37845

TitleMagnetic Liposomes based on Nickel Ferrite Nanoparticles for biomedical applications
Author(s)Rodrigues, Ana Rita O.
Gomes, I. Tarroso
Almeida, B. G.
Araújo, João P.
Castanheira, Elisabete M. S.
Coutinho, Paulo J. G.
KeywordsMagnetic nanoparticles
Cancer therapy
Liposomes
Drug nanocarriers
Issue dateJun-2015
PublisherRoyal Society of Chemistry
JournalPhysical Chemistry Chemical Physics
Abstract(s)Nickel ferrite nanoparticles with superparamagnetic behavior at room temperature were synthesized by a coprecipitation method. These magnetic nanoparticles were either covered with a lipid bilayer, forming dry magnetic liposomes (DMLs), or entrapped in liposomes, originating aqueous magnetoliposomes (AMLs). A new and promising method for the synthesis of DMLs is described. The presence of the lipid bilayer in DMLs was confirmed by FRET (Förster Resonance Energy Transfer) measurements between the fluorescent-labeled lipids NBD-C12-HPC (NBD acting as donor) included in the second lipid layer and rhodamine B-DOPE (acceptor) in the first lipid layer. An average donor-acceptor distance of 3 nm was estimated. Assays of the non-specific interactions of magnetoliposomes with biological membranes (modeled using giant unilamellar vesicles, GUVs) were performed. Membrane fusion between both aqueous and dry magnetoliposomes and GUVs was confirmed by FRET, which is an important result regarding applications of these systems both as hyperthermia agents and antitumor drug nanocarriers.
TypeArticle
URIhttp://hdl.handle.net/1822/37845
DOI10.1039/C5CP01894C
ISSN1463-9076
1463-9084
Publisher versionThe original publication is available at: http://pubs.rsc.org/en/content/articlehtml/2015/cp/c5cp01894c
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:CDF - FAMO - Artigos/Papers (with refereeing)

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Magnetic Liposomes based on Nickel Ferrite_Supplementary_Information.pdf
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Informação Suplementar516,65 kBAdobe PDFView/Open

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