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TitleMagnetic Liposomes based on Nickel Ferrite Nanoparticles for biomedical applications
Author(s)Rodrigues, Ana Rita O.
Gomes, I. Tarroso
Almeida, B. G.
Araújo, João P.
Castanheira, Elisabete M. S.
Coutinho, Paulo J. G.
KeywordsMagnetic nanoparticles
Cancer therapy
Drug nanocarriers
Issue dateJun-2015
PublisherRoyal Society of Chemistry
JournalPhysical Chemistry Chemical Physics
Abstract(s)Nickel ferrite nanoparticles with superparamagnetic behavior at room temperature were synthesized by a coprecipitation method. These magnetic nanoparticles were either covered with a lipid bilayer, forming dry magnetic liposomes (DMLs), or entrapped in liposomes, originating aqueous magnetoliposomes (AMLs). A new and promising method for the synthesis of DMLs is described. The presence of the lipid bilayer in DMLs was confirmed by FRET (Förster Resonance Energy Transfer) measurements between the fluorescent-labeled lipids NBD-C12-HPC (NBD acting as donor) included in the second lipid layer and rhodamine B-DOPE (acceptor) in the first lipid layer. An average donor-acceptor distance of 3 nm was estimated. Assays of the non-specific interactions of magnetoliposomes with biological membranes (modeled using giant unilamellar vesicles, GUVs) were performed. Membrane fusion between both aqueous and dry magnetoliposomes and GUVs was confirmed by FRET, which is an important result regarding applications of these systems both as hyperthermia agents and antitumor drug nanocarriers.
Publisher versionThe original publication is available at:
AccessRestricted access (UMinho)
Appears in Collections:CDF - FAMO - Artigos/Papers (with refereeing)

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