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TitleFolk medicinal plant extracts as a source of biomolecules with antifungal properties against Candida species
Author(s)Martins, Natália
Ferreira, Isabel C. F. R.
Barros, Lillian
Carvalho, Ana Maria
Henriques, Mariana
Silva, Sónia Carina
KeywordsMedicinal plants
Phenolic extracts
Antifungal potential
Candida species
Issue dateAug-2015
PublisherOMICS Publishing Group
JournalChemotherapy: Open Access
CitationMartins, N.; Ferreira, Isabel C. F. R.; Barros, Lillian; Carvalho, Ana Maria; Henriques, Mariana; Silva, Sónia Carina, Folk medicinal plant extracts as a source of biomolecules with antifungal properties against Candida species. Chemotherapy: Open Access, 4(2), 54-54, 2015
Abstract(s)Increasing rates of opportunistic fungal infections and microorganisms with drug-resistance have been observed. Candida species are the most common pathogens, considered the fourth leading cause of hematogenous infections [1]. Thus, it is crucial to discover alternatives to the current antifungal agents. Healing properties of medicinal plants are widely recognized, but some properties and the related mechanisms of action remain unknown. Therefore, the anti-Candida potential of hydromethanolic extracts obtained from ten folk medicinal plants (Echinacea purpurea L.; Eucalyptus globulus Labill.; Foeniculum vulgare Mill.; Juglans regia L.; Matricaria recutita L.; Melissa officinalis L.; Pterospartum tridentatum L.; Rosa canina L.; Rubus ulmifolius L. and Tabebuia impetiginosa L.) was evaluated, by using disc diffusion assay and determination of minimal inhibitory concentrations by microdilution method. J. regia was the most effective, inhibiting the growth of the tested nineteen Candida strains (halo diameter varying between 9-14 mm) and causing a growth reduction of 3-5 Log(CFUs) for Candida parapsilosis and C. tropicalis, and 0.5-2.5 for C. albicans and C. glabrata. E. globulus also exhibit a significant potential, being effective against seventeen Candida strains (halo diameter ranging between 9-21 mm) and causing a growth reduction of 2-5 Log(CFUs). P. tridentatum and R. ulmifolius showed similar antifungal effects, being effective against six Candida strains (halo diameter ranging between 9-19 mm). So, as main conclusions, hydromethanolic extracts of E. globulus and J. regia could constitute promissory alternatives to the current antifungal agents, but more detailed studies are needed in order to identify the bioactive compounds and related mechanism of action.
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AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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