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https://hdl.handle.net/1822/36841
Título: | Zearalenone and its derivatives α-Zearalenol and β-Zearalenol decontamination by Saccharomyces cerevisiae strains isolated from bovine forage |
Autor(es): | Keller, Luiz Abrunhosa, Luís Keller, Kelly Rosa, Carlos Alberto Cavaglieri, Lilia Venâncio, Armando |
Palavras-chave: | ZEA α-ZOL β-ZOL Detoxification Adsorption Saccharomyces cerevisiae ß-ZOL |
Data: | Ago-2015 |
Editora: | MDPI Publishing |
Revista: | Toxins |
Citação: | Keller, Luiz; Abrunhosa, Luís; Keller, Kelly; Rosa, Carlos Alberto; Cavaglieri, Lilia; Venâncio, Armando, Zearalenone and its derivatives α-Zearalenol and β-zearalenol decontamination by Saccharomyces cerevisiae strains isolated from bovine forage. Toxins, 7(8), 3297-3308, 2015 |
Resumo(s): | Zearalenone (ZEA) and its derivatives are mycotoxins with estrogenic effects on mammals. The biotransformation for ZEA in animals involves the formation of two major metabolites, - and -zearalenol (-ZOL and -ZOL), which are subsequently conjugated with glucuronic acid. The capability of Saccharomyces cerevisiae strains isolated from silage to eliminate ZEA and its derivatives -ZOL and -ZOL was investigated as, also, the mechanisms involved. Strains were grown on Yeast Extract-Peptone-Dextrose medium supplemented with the mycotoxins and their elimination from medium was quantified over time by HPLC-FL. A significant effect on the concentration of ZEA was observed, as all the tested strains were able to eliminate more than 90% of the mycotoxin from the culture medium in two days. The observed elimination was mainly due to ZEA biotransformation into -ZOL (53%) and -ZOL (8%) rather than to its adsorption to yeast cells walls. Further, the biotransformation of -ZOL was not observed but a small amount of -ZOL (6%) disappeared from culture medium. ZEA biotransformation by yeasts may not be regarded as a full detoxification process because both main end-products are still estrogenic. Nonetheless, it was observed that the biotransformation favors the formation of -ZOL which is less estrogenic than ZEA and -ZOL. This metabolic effect is only possible if active strains are used as feed additives and may play a role in the detoxification performance of products with viable S. cerevisiae cells. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/36841 |
DOI: | 10.3390/toxins7083297 |
ISSN: | 2072-6651 |
e-ISSN: | 2072-6651 |
Versão da editora: | http://www.mdpi.com/2072-6651/7/8/3297 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_22343_1.pdf | 580,58 kB | Adobe PDF | Ver/Abrir |