Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/36612

TítuloCell engineering by the internalization of bioinstructive micelles for enhanced bone regeneration
Autor(es)Santo, Vitor E.
Ratanavaraporn, Juthamas
Sato, Keisuke
Gomes, Manuela E.
Mano, J. F.
Reis, R. L.
Tabata, Yasuhiko
Palavras-chaveBone regeneration
Intracellular delivery
Mesenchymal stem cell
Micelle
Nanoparticle
Tissue engineering
DataAgo-2015
EditoraFuture Medicine
RevistaNanomedicine
CitaçãoSanto V. E., Ratanavaraporn J., Sato K., Gomes M. E., Mano J. F., Reis R. L., Tabata Y. Cell engineering by the internalization of bioinstructive micelles for enhanced bone regeneration, Nanomedicine, Vol. 10, Issue 11, pp. 1707-1721, doi:10.2217/nnm.15.11 , 2015
Resumo(s)To direct precursor cells toward the osteoblastic lineage, by using an intracellular nanocarrier releasing dexamethasone. Materials & methods: Biodegradable gelatinbased micelles entrapped dexamethasone (dex-micelles). Internalization efficiency and biocompatibility of dex-micelles and their potency for in vitro osteogenic differentiation and in vivo bone regeneration were assessed. Results: Dex-micelles were internalized by rat bone marrow mesenchymal stem cells and demonstrated a pH-responsive release profile and an enhancement of 2D and 3D in vitro osteogenic differentiation. In vivo implantation of gelatin scaffolds seeded with rat bone marrow mesenchymal stem cells precultured for 24 h with dex-micelles promoted a significant enhancement of de novo bone formation in a rat ulna defect, in a dose-dependent manner. Conclusion: The proposed intracellular delivery system is a powerful tool to promote bone regeneration.
Tipoarticle
URIhttp://hdl.handle.net/1822/36612
DOI10.2217/nnm.15.11
ISSN1743-5889
Versão da editorahttp://www.futuremedicine.com/doi/abs/10.2217/nnm.15.11
Arbitragem científicayes
AcessoopenAccess
Aparece nas coleções:3B’s - Artigos em revistas/Papers in scientific journals

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