Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/36084

TitleMicrobiome in cystic fibrosis: shaping polymicrobial interactions for advances in antibiotic therapy
Author(s)Lopes, Susana Patrícia
Azevedo, Nuno F.
Pereira, Maria Olívia
KeywordsCystic fibrosis lung disease
Polymicrobial biofilms
Microbial interactions
Antibiotic therapy
Cystic fibrosis
Microbial diversity
Issue dateAug-2015
PublisherInforma Healthcare
JournalCritical Reviews in Microbiology
CitationLopes, Susana Patrícia ; Azevedo, N.; Pereira, Maria Olívia, Microbiome in cystic fibrosis - shaping polymicrobial interactions for advances in antibiotic therapy. Critical Reviews in Microbiology, 41(3), 353-365, 2015
Abstract(s)Recent molecular methodologies have demonstrated a complex microbial ecosystem in cystic fibrosis (CF) airways, with a wide array of uncommon microorganisms co-existing with the traditional pathogens. Although there are lines of evidence supporting the contribution of some of those emergent species for lung disease chronicity, clinical significance remains uncertain for most cases. A possible contribution for disease is likely to be related with the dynamic interactions established between microorganisms within the microbial community and with the host. If this is the case, management of CF will only be successful upon suitable and exhaustive modulation of such mixed ecological processes, which will also be useful to predict the effects of new therapeutic interventions.
TypeArticle
URIhttp://hdl.handle.net/1822/36084
DOI10.3109/1040841X.2013.847898
ISSN1040-841X
e-ISSN1549-7828
Publisher versionhttp://informahealthcare.com/journal/mby
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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