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TitleActivity of phenolic compounds from plant origin against Candida species
Author(s)Martins, Natália
Barros, Lillian
Henriques, Mariana
Silva, Sónia Carina
Ferreira, Isabel C. F. R.
Plant extracts
Phenolic compounds
Antifungal activity
Candida species
Issue dateNov-2015
JournalIndustrial Crops and Products
CitationMartins, Natália; Barros, Lillian; Henriques, Mariana; Silva, Sónia Carina; Ferreira, Isabel C. F. R., Activity of phenolic compounds from plant origin against Candida species. Industrial Crops and Products, 74, 648-670, 2015
Abstract(s)Candida albicans and other Candida species have been highly associated with several opportunistic fungal infections. Their ability to develop host infections is incited by different determinants, being virulence factors the most highlighted. Molecular targets of the antifungal drugs are crucial components for determination of yeast survival. Ergosterol, nucleic acids and glucan are the most studied molecular targets to destroy Candida species, being considered the basis of the development of new antifungal drugs. However, increasing levels of resistant Candida species to the current antifungal drugs have been observed, making ineffective those agents. Thus, other therapies more effective and safer than the current ones, are being studied, namely the use plant of extracts enriched in phenolic compounds. In this sense, this manuscript provide an historical perspective of the opportunistic fungal infections, molecular targets of the current anti-Candida drugs, as well as a general description of the active principles present in plants, focused on the antifungal potential of whole plant extracts and isolated phenolic compounds, against Candida species.
Publisher version
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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