Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/35305

TitleFolic acid-tagged protein nanoemulsions loaded with CORM-2 enhance the survival of mice bearing subcutaneous A20 lymphoma tumors
Author(s)Loureiro, Ana Isabel Sá
Bernardes, Gonçalo J. L.
Shimanovich, Ulyana
Sárria, M. P.
Nogueira, Eugénia
Preto, Ana
Gomes, Andreia
Paulo, Artur Cavaco
Keywordsprotein nanoemulsions
folic acid
CORM-2
specific uptake
targeted drug delivery
Issue dateJul-2015
PublisherElsevier B.V.
JournalNanomedicine: Nanotechnology, Biology, and Medicine
CitationLoureiro, Ana; Bernardes, Gonçalo J. L.; Shimanovich, Ulyana; Sárria, M. P.; Nogueira, Eugénia; Preto, Ana; Gomes, Andreia C.; Paulo, Artur Cavaco, Folic acid-tagged protein nanoemulsions loaded with CORM-2 enhance the survival of mice bearing subcutaneous A20 lymphoma tumors. Nanomedicine: Nanotechnology, Biology, and Medicine, 11(5), 1077-1083, 2015
Abstract(s)Folic Acid (FA)-tagged protein nanoemulsions were found to be preferentially internalized on B-cell lymphoma cell line (A20 cell line), which, for the first time, are reported to express folate receptor (FR)-alpha. Carbon monoxide releasing molecule-2 (CORM-2) was incorporated in the oil phase of the initial formulation. FA-functionalized nanoemulsions loaded with CORM-2 exhibited a considerable antitumor effect and an increased survival of BALB/c mice bearing subcutaneous A20 lymphoma tumors. The developed nanoemulsions also demonstrated to be well tolerated by these immunocompetent mice. Thus, the results obtained in this study demonstrate that FA-tagged protein nanoemulsions can be successfully used in cancer therapy, with the important ability to delivery drugs intracellularly.
TypeArticle
URIhttp://hdl.handle.net/1822/35305
DOI10.1016/j.nano.2015.02.022
ISSN1549-9634
e-ISSN1549-9642
Publisher versionhttp://www.sciencedirect.com/science/article/pii/S1549963415000726
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series
DBio - Artigos/Papers

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