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TitleHollow chitosan/alginate nanocapsules for bioactive compound delivery
Author(s)Rivera, M. C.
Pinheiro, A. C.
Bourbon, A. I.
Cerqueira, M. A.
Vicente, A. A.
KeywordsBiodegradable polysaccharides
Functional compounds
Issue dateAug-2015
PublisherElsevier B.V.
JournalInternational Journal of Biological Macromolecules
CitationRivera, Melissa C.; Pinheiro, A. C.; Bourbon, A. I.; Cerqueira, M. A.; Vicente, A. A., Hollow chitosan/alginate nanocapsules for bioactive compound delivery. International Journal of Biological Macromolecules, 79, 95-102, 2015
Abstract(s)This work aimed at the development of biodegradable nanocapsules as carriers of two bioactive compounds, 5-aminosalycilic acid and glycomacropeptide. Nanocapsules were produced through layer-by-layer (LbL) deposition of chitosan (CH) and alginate (ALG) layers on polystyrene nanoparticles. The bioactive compounds were incorporated on the third layer of the nanocapsules being its encapsulation efficiency and release behaviour evaluated. The LbL deposition process, stability, morphology and size of the multilayer nanocapsules were monitored by means of zeta potential and transmission electron microscopy (TEM). The bioactive compounds release from the CH/ALG nanocapsules was successfully described by a mathematical model (linear superimposition model LSM), which allowed concluding that bioactive compounds release is due to both Brownian motion and the polymer relaxation of the CH/ALG layers. Final results demonstrated that the synthesized LbL hollow nanocapsules presented spherical morphology and a good capacity to encapsulate different bioactive compounds, being the best results obtained for the system containing 5-aminosalycilic acid (with an encapsulation efficiency of approximately 70%). CH/ALG multilayer nanocapsules could be a promising carrier of bioactive compounds for applications in food and pharmaceutical industries.
Publisher version
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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