Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/35149

TitleMicrobial surfactants: fundamentals and applicability in the formulation of nano-sized drug delivery vectors
Author(s)Rodrigues, L. R.
KeywordsBiosurfactants
Microemulsions
Nanoparticles
Drug delivery systems
Self-aggregation
Issue dateJul-2015
PublisherElsevier Ltd.
JournalJournal of Colloid and Interface Science
CitationRodrigues, L. R., Microbial surfactants: fundamentals and applicability in the formulation of nano-sized drug delivery vectors. Journal of Colloid and Interface Science, 449, 304-316, 2015
Abstract(s)Microbial surfactants, so-called biosurfactants, comprise a wide variety of structurally distinct amphipathic molecules produced by several microorganisms. Besides exhibiting surface activity at the interfaces, these molecules present powerful characteristics including high biodegradability, low toxicity and special biological activities (e.g. antimicrobial, antiviral, anticancer, among others), that make them an alternative to their chemical counterparts. Several medical-related applications have been suggested for these molecules, including some reports on their potential use in the formulation of nano-sized drug delivery vectors. However, despite their promises, due to the generalized lack of knowledge on microbial surfactants phase behavior and stability under diverse physicochemical conditions, these applications remain largely unexplored, thus representing an exciting field of research. These nano-sized vectors are a powerful approach towards the current medical challenges regarding the development of efficient and targeted treatments for several diseases. In this review, a special emphasis will be given to nanoparticles and microemulsions. Nanoparticles are very auspicious as their size, shape and stability can be manipulated by changing the environmental conditions. On the other hand, the easiness of formulation, as well as the broad possibilities of administration justifies the recent popularity of the microemulsions. Notwithstanding, both vector types still require further developments to overcome some critical limitations related with toxicity and costs, among others. Such developments may include the search for other system components, as the microbial surfactants, that can display improved features.
TypeArticle
URIhttp://hdl.handle.net/1822/35149
DOI10.1016/j.jcis.2015.01.022
ISSN0021-9797
e-ISSN1095-7103
Publisher versionhttp://www.journals.elsevier.com/journal-of-colloid-and-interface-science
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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