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|Title:||Antimicrobial lubricant formulations containing poly(hydroxybenzene)-trimethoprim conjugates synthesized by tyrosinase|
Botelho, C. M.
Abreu, Ana S.
Carla Manuela Pereira Marinho da
Paulo, Artur Cavaco
|Journal:||Applied Microbiology and Biotechnology|
|Citation:||Gonçalves, Idalina; Botelho, C. M.; Teixeira, Ana; Abreu, A. S.; Hilliou, L.; Silva, Carla; Paulo, Artur Cavaco, Antimicrobial lubricant formulations containing poly(hydroxybenzene)-trimethoprim conjugates synthesized by tyrosinase. Applied Microbiology and Biotechnology, 99(10), 4225-4235, 2015|
|Abstract(s):||Poly(hydroxybenzene)-trimethoprim conjugates were prepared using methylparaben as substrate of the oxida- tive enzyme tyrosinase. MALDI-TOF MS analysis showed that the enzymatic oxidation of methylparaben alone leads to the poly(hydroxybenzene) formation. In the presence of tri- methoprim, the methylparaben tyrosinase oxidation leads poly(hydroxybenzene)-trimethoprim conjugates. All of these compounds were incorporated into lubricant hydroxyethyl cellulose/glycerol mixtures. Poly(hydroxybenzene)-trimetho- prim conjugates were the most effective phenolic structures against the bacterial growth reducing by 96 and 97 % of Escherichia coli and Staphylococcus epidermidis suspen- sions, respectively (after 24 h). A novel enzymatic strategy to produce antimicrobial poly(hydroxybenzene)-antibiotic conjugates is proposed here for a wide range of applications on the biomedical field.|
|Appears in Collections:||CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series|
IPC - Artigos em revistas científicas internacionais com arbitragem