Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/35093

TitleAntimicrobial lubricant formulations containing poly(hydroxybenzene)-trimethoprim conjugates synthesized by tyrosinase
Author(s)Gonçalves, Idalina
Botelho, C. M.
Teixeira, Ana
Abreu, Ana S.
Hilliou, L.
Carla Manuela Pereira Marinho da
Paulo, Artur Cavaco
KeywordsMethylparaben
Trimethoprim
Tyrosinase
Poly(hydroxybenzene)
Conjugates
Antimicrobial
Issue dateMay-2015
PublisherSpringer
JournalApplied Microbiology and Biotechnology
CitationGonçalves, Idalina; Botelho, C. M.; Teixeira, Ana; Abreu, A. S.; Hilliou, L.; Silva, Carla; Paulo, Artur Cavaco, Antimicrobial lubricant formulations containing poly(hydroxybenzene)-trimethoprim conjugates synthesized by tyrosinase. Applied Microbiology and Biotechnology, 99(10), 4225-4235, 2015
Abstract(s)Poly(hydroxybenzene)-trimethoprim conjugates were prepared using methylparaben as substrate of the oxida- tive enzyme tyrosinase. MALDI-TOF MS analysis showed that the enzymatic oxidation of methylparaben alone leads to the poly(hydroxybenzene) formation. In the presence of tri- methoprim, the methylparaben tyrosinase oxidation leads poly(hydroxybenzene)-trimethoprim conjugates. All of these compounds were incorporated into lubricant hydroxyethyl cellulose/glycerol mixtures. Poly(hydroxybenzene)-trimetho- prim conjugates were the most effective phenolic structures against the bacterial growth reducing by 96 and 97 % of Escherichia coli and Staphylococcus epidermidis suspen- sions, respectively (after 24 h). A novel enzymatic strategy to produce antimicrobial poly(hydroxybenzene)-antibiotic conjugates is proposed here for a wide range of applications on the biomedical field.
Typearticle
URIhttp://hdl.handle.net/1822/35093
DOI10.1007/s00253-015-6509-1
ISSN0175-7598
e-ISSN1432-0614
Publisher versionhttp://www.springer.com/chemistry/biotechnology/journal/253
Peer-Reviewedyes
AccessopenAccess
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series
IPC - Artigos em revistas científicas internacionais com arbitragem

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