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TitlePolymeric micellar drug carriers with fluorescent properties
Author(s)Abreu, Ana Sofia Lemos Machado
Sá, Arsénio Vasconcelos
Oliveira, Manuel
Moura, I.
Machado, A. V.
Issue date28-Apr-2015
Abstract(s)Self-assembling polymeric surfactants, based on amphiphilic block copolymers into nanosized aggregates in aqueous solution, are of great interest in the biomedical fields as one class of promising carrier systems, for drug delivery, gene therapy and diagnostic biosensors.[1] The incorporation of fluorescent probes into polymeric micelles has been fulfilled either by physically encapsulation or chemically attachment of fluorophores. [2] These micelle-based fluorescent probes not only facilitate better dispersion of fluorophores in biological environments, but also reduce their cytotoxicity by avoiding direct contact with normal cells or tissues. In this work we present new water soluble amphiphilic polymers, poly(acrylic acid) macroRAFT (PAA) 1 and poly(acrylic acid)-block-poly(9-vinylanthracene) (PAA-b-P9VA) 2, for the production of the mixed fluorescent micelles. Fluorescence assays were performed to monitoring the effect of their ratio on the formation of mixed micelles and to determine 1’s critical micelle concentration (cmc). The cmc was also evaluated by surface tension measurements.
TypeConference paper
AccessOpen access
Appears in Collections:IPC - Textos completos em actas de encontros científicos internacionais com arbitragem

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