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TitleCurrent concepts and challenges in osteochondral tissue engineering and regenerative medicine
Author(s)Yan, Leping
Oliveira, Joaquim M.
Oliveira, Ana Leite
Reis, R. L.
KeywordsOsteochondral tissue engineering
Layered scaffold
Interface engineering
Clinical trial
Pluripotent stem cells
Issue date2015
PublisherAmerican Chemical Society
JournalACS biomaterials science & engineering
CitationYan L. P., Oliveira J. M., Oliveira A. L., Reis R. L. Current Concepts and Challenges in Osteochondral Tissue Engineering and Regenerative Medicine, ACS Biomaterials Science & Engineering, doi:10.1021/ab500038y, 2015
Abstract(s)In the last few years, great progress has been made to validate tissue engineering strategies in preclinical studies and clinical trials on the regeneration of osteochondral defects. In the preclinical studies, one of the dominant strategies comprises the development of biomimetic/bioactive scaffolds, which are used alone or incorporated with growth factors and/or stem cells. Many new trends are emerging for modulation of stem cell fate towards osteogenic and chondrogenic differentiations, but bone/cartilage interface regeneration and physical stimulus have been showing great promise. Besides the matrix-associated autologous chondrocyte implantation (MACI) procedure, the matrix-associated stem cells implantation (MASI) and layered scaffolds in acellular or cellular strategy are also applied in clinic. This review outlines the progresses at preclinical and clinical levels, and identifies the new challenges in osteochondral tissue engineering. Future perspectives are provided, e.g., the applications of extracellular matrix-like biomaterials, computer-aided design/manufacture of osteochondral implant and reprogrammed cells for osteochondral regeneration.
Description"Publication Date (Web): February 20, 2015"
Publisher version
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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