Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/34716

TitleRevisiting phage therapy: new applications for old resources
Author(s)Nóbrega, Franklin Luzia
Costa, A. R.
Kluskens, Leon
Azeredo, Joana
KeywordsBacteriophages
Phage therapy
Genetic modification
Recombineering
Issue date2015
PublisherElsevier B.V.
JournalTrends in Microbiology
Abstract(s)The success of phage therapy is dependent on the development of strategies able to overcome the limitations of bacteriophages as therapeutic agents, the creation of an adequate regulatory framework, the implementation of safety protocols, and the acceptance by the general public. Many approaches have been proposed to circumvent phages intrinsic limitations but none have proved to be completely satisfactory. In this review we present the major hurdles of phage therapy and the solutions proposed to circumvent them. A thorough discussion on the advantages and drawbacks of these solutions is provided and special attention is given to genetic modification of phages as an achievable strategy to shape bacteriophages to exhibit desirable biological properties.
Typearticle
URIhttp://hdl.handle.net/1822/34716
DOI10.1016/j.tim.2015.01.006
ISSN0966-842X
Publisher versionhttp://www.cell.com/trends/microbiology/home
Peer-Reviewedyes
AccessopenAccess
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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