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TitleHeterologous production of curcuminoids
Author(s)Rodrigues, Joana Lúcia Lima Correia
Prather, Kristala L. J.
Kluskens, Leon
Rodrigues, L. R.
E. coli
Heterologous expression
Curcuminoid synthase
4-coumarate-CoA ligase
Tyrosine ammonia lyase
Issue dateMar-2015
PublisherAmerican Society for Microbiology (ASM)
JournalMicrobiology and molecular biology reviews
CitationRodrigues, Joana Lúcia; Prather, Kristala; Kluskens, Leon; Rodrigues, L. R., Heterologous production of curcuminoids. Microbiology and Molecular Biology Reviews, 79(1), 39-60, 2015
Abstract(s)Curcuminoids, components of the rhizome of turmeric, show several beneficial biological activities, including anticarcinogenic, antioxidant, anti-inflammatory, and antitumor activities. Despite their numerous pharmaceutically important properties, the low natural abundance of curcuminoids represents a major drawback for their use as therapeutic agents. Therefore, they represent attractive targets for heterologous production and metabolic engineering. The understanding of biosynthesis of curcuminoids in turmeric made remarkable advances in the last decade, and as a result, several efforts to produce them in heterologous organisms have been reported. The artificial biosynthetic pathway (e.g., in Escherichia coli) can start with the supplementation of the amino acid tyrosine or phenylalanine or of carboxylic acids and lead to the production of several natural curcuminoids. Unnatural carboxylic acids can also be supplemented as precursors and lead to the production of unnatural compounds with possibly novel therapeutic properties. In this paper, we review the natural conversion of curcuminoids in turmeric and their production by E. coli using an artificial biosynthetic pathway. We also explore the potential of other enzymes discovered recently or already used in other similar biosynthetic pathways, such as flavonoids and stilbenoids, to increase curcuminoid yield and activity.
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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