Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/34559

TítuloNatural-based nanocomposites for bone tissue engineering and regenerative medicine : a review
Autor(es)Pina, S.
Oliveira, J. M.
Reis, R. L.
Palavras-chaveBone Tissue Engineering
Calcium phosphates
nanocomposites
natural polymers
regenerative medicine
DataJan-2015
EditoraWiley
RevistaAdvanced Materials
CitaçãoPina S., Oliveira J. M., Reis R. L. Natural-based Nanocomposites for Bone Tissue Engineering and Regenerative Medicine: A Review, Advanced Materials, Vol. 27, Issue 7, pp. 1143-1169, doi:10.1002/adma.201403354, 2015
Resumo(s)Tissue engineering and regenerative medicine has been providing exciting technologies for the development of functional substitutes aimed to repair and regenerate damaged tissues and organs. Inspired by the hierarchical nature of bone, nanostructured biomaterials are gaining a singular attention for tissue engineering, owing their ability to promote cell adhesion and proliferation, and hence new bone growth, compared with conventional microsized materials. Of particular interest are nanocomposites involving biopolymeric matrices and bioactive nanosized fi llers. Biodegradability, high mechanical strength, and osteointegration and formation of ligamentous tissue are properties required for such materials. Biopolymers are advantageous due to their similarities with extracellular matrices, specifi c degradation rates, and good biological performance. By its turn, calcium phosphates possess favorable osteoconductivity, resorbability, and biocompatibility. Herein, an overview on the available natural polymer/calcium phosphate nanocomposite materials, their design, and properties is presented. Scaffolds, hydrogels, and fi bers as biomimetic strategies for tissue engineering, and processing methodologies are described. The specifi c biological properties of the nanocomposites, as well as their interaction with cells, including the use of bioactive molecules, are highlighted. Nanocomposites in vivo studies using animal models are also reviewed and discussed.  
Tipoarticle
URIhttp://hdl.handle.net/1822/34559
DOI10.1002/adma.201403354
Versão da editorahttp://onlinelibrary.wiley.com/doi/10.1002/adma.201403354/abstract
Arbitragem científicayes
AcessoopenAccess
Aparece nas coleções:3B’s - Artigos em revistas/Papers in scientific journals

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