Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/33676

TitleThe significance of augmentedhigh-grade squamous intraepithelial lesion detection on pap test examination: partial results from the RODEO study team
Author(s)Scapulatempo-Neto, Cristovam
Fregnani, José Humberto T. G.
Campacci, Natália
Resende, Júlio Cesar Possati
Longatto Filho, Adhemar
KeywordsPap test
Cytological screening
Liquid-based cytology
Pap test
SurePath TM
Cytopathology
SurePath™
Issue date2013
PublisherKarger AG
JournalActa Cytologica
Abstract(s)OBJECTIVE: This study sought to ascertain the significance of augmented high-grade squamous intraepithelial lesion (HSIL) detection by Pap test using both conventional smear and liquid-based cytology (LBC) in a high-risk population. STUDY DESIGN: We conducted a direct-to-vial study to compare the diagnostic performance of Pap smear versus LBC in a high-risk population of women referred for colposcopy at a gynecologic ambulatory clinic at the Barretos Cancer Hospital in Brazil during 2011. RESULTS: The detection of both low-grade squamous intraepithelial lesions (LSILs) and HSILs was significantly greater (p = 0.04 and p = 0.033, respectively) in the LBC arm [84 LSIL cases (5.7%) and 148 HSIL cases (10.1%)] than in the conventional smear arm [66 LSIL cases (4.1%) and 126 HSIL cases (7.9%)]; however, no differences were found for invasive squamous carcinoma or adenocarcinoma (p = 0.678). Of 3,071 women who were examined cytologically (1,604 conventional preparations and 1,467 LBC) and colposcopically, biopsies were available for 279 conventional preparations (17.6%) and 325 LBC preparations (22.2%). No significant differences were found between the methods with respect to diagnostic performance. CONCLUSION: LBC was significantly superior to conventional smears for the detection of LSILs and HSILs, but these results did not influence biopsy confirmation. Both methods showed similar performances with high positive predictive values but very low sensitivities.
TypeArticle
URIhttp://hdl.handle.net/1822/33676
DOI10.1159/000351789
ISSN0001-5547
Publisher versionhttp://www.karger.com/Article/Pdf/351789
Peer-Reviewedyes
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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