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TitleArterial stiffness and influences of the metabolic syndrome : a cross-countries study
Author(s)Scuteri, Angelo
Cunha, Pedro Guimarães
Rosei, E. Agabiti
Bekaert, Sofie
Cockcrofti, John R.
Cotter, Jorge
Cucca, Francesco
De Buyzere, Marc L.
De Meyer, Tim
Ferrucci, Luigi
Franco, Franco
Gale, Nichols
Gillebert, Thierry C.
Hofman, A.
Langlois, Michel
Laucevicius, Aleksandras
Laurent, Stephane
Raso, Francesco U.S. Mattace
Morrell, Cristopher H.
Muiesan, Maria Lorenza
Munnery, Margaret M.
Navickas, Rokas
Oliveira, Pedro
Orru, Marco
Pilia, Maria Grazia
Rietzschel, Ernst R.
Ryliskyte, Ligita
Salvetti, Massimo
Schlessinger, David
Sousa, Nuno
Stefanadis, Christodoulos
Strait, James
Van Daele, Caroline
Villa, Isabel
Vlachopoulos, Charalambos
Witteman, Jacqueline
Xaplanteris, Panagiotis
Nilsson, Peter
Lakatta, Edward G.
MARE Consortium
KeywordsArterial stiffness
Cross-cultural comparison
Metabolic syndrome
Pulse wave velocity
Issue dateApr-2014
Abstract(s)Specific clusters of metabolic syndrome (MetS) components impact differentially on arterial stiffness, indexed as pulse wave velocity (PWV). Of note, in several population-based studies participating in the MARE (Metabolic syndrome and Arteries REsearch) Consortium the occurrence of specific clusters of MetS differed markedly across Europe and the US. The aim of the present study was to investigate whether specific clusters of MetS are consistently associated with stiffer arteries in different populations. We studied 20,570 subjects from 9 cohorts representing 8 different European countries and the US participating in the MARE Consortium. MetS was defined in accordance with NCEP ATPIII criteria as the simultaneous alteration in >= 3 of the 5 components: abdominal obesity (W), high triglycerides (T), low HDL cholesterol (H), elevated blood pressure (B), and elevated fasting glucose (G). PWV measured in each cohort was "normalized" to account for different acquisition methods. MetS had an overall prevalence of 24.2% (4985 subjects). MetS accelerated the age-associated increase in PWV levels at any age, and similarly in men and women. MetS clusters TBW, GBW, and GTBW are consistently associated with significantly stiffer arteries to an extent similar or greater than observed in subjects with alteration in all the five MetS components - even after controlling for age, sex, smoking, cholesterol levels, and diabetes mellitus - in all the MARE cohorts. In conclusion, different component clusters of MetS showed varying associations with arterial stiffness (PWV). (C) 2014 Elsevier Ireland Ltd. All rights reserved.
Publisher version
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Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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