Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/33383

TitleMagnetic cells with surface modified Fe3O4 spherical and rod-shaped nanoparticles for tissue engineering and regenerative medicine applications
Author(s)Gil, Sara
Correia, Clara R.
Mano, J. F.
KeywordsMagnetic nanoparticles
Smart responsive systems
Targeted cell delivery
Three dimensional (3D) cell culture
Tissue engineering.
Issue dateJun-2014
PublisherWiley
JournalJournal of Tissue Engineering and Regenerative Medicine
CitationGil S., Correia C. R., Mano J. F. Magnetic cells with surface modified Fe3O4 spherical and rod-shaped nanoparticles for tissue engineering and regenerative medicine applications, Journal of Tissue Engineering and Regenerative Medicine, Vol. 8, pp. 49-50, 2014
Abstract(s)Although magnetic nanoparticles (MNPs) have fueled the field of nanotechnology in the last few years, the application of MNPs in cell-based therapies has seldom been considered. We hypothesized that magnetically labeled cells could be delivered by intravenous injection, and guided to sites of injury within the body, upon magnetic actuation.Moreover, cells could be retained in the damaged site, creating three dimensional tissue constructs that mimic the structure and functional properties of the native tissue. In this work cells were loaded with superparamagnetic Fe3O4 sphere or rod-shaped nanoparticles. The influence of MNPs shape, size, concentration, and time of incubation on cellular internalization was analyzed. Additionally, cell-sheets were successfully generated by magnetic force-based tissue engineering (TE).
TypeAbstract
URIhttp://hdl.handle.net/1822/33383
ISSN1932-6254
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:3B’s - Resumos em livros de atas de conferências - indexados no ISI Web of Science

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