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|Title:||Functional chitosan microcarriers for selective cell attachment and expansion|
|Author(s):||Custódio, Catarina Almeida|
Cerqueira, M. T.
Marques, A. P.
Reis, R. L.
Mano, J. F.
|Journal:||Journal of Tissue Engineering and Regenerative Medicine|
|Citation:||Custódio C. A., Cerqueira M. T., Marques A. P., Reis R. L., Mano J. F. Functional chitosan microcarriers for selective cell attachment and expansion, Termis EU 2014 , 2014|
|Abstract(s):||The success of many stem cell applications in the biomedical field is highly dependent on the development of reliable techniques either for isolation or selection of specific cell populations with a very high yield and purity.1 In this work we propose the use of chitosan microparticles (μPs) to capture a specific cell type based in the concept of antibody-antigen binding. Our goal was to create new biomaterials capable of selecting within a heterotypic cell suspension, a specific sub-population, and supporting subsequent cell expansion. Such system simultaneously allows the selection and acts as a microcarrier for a specific target, thus reducing cell manipulation and time-consumption.|
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