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|Title:||Bacterial cellulose : production and applications|
|Author(s):||Gama, F. M.|
Andrade, Fábia K.
|Citation:||Gama, F. M.; Andrade, F. K.; Domingues, Lucília; Dourado, Fernando, Bacterial cellulose: production and applications. 1st Meeting of the Institute for Biotechnology and Bioengineering. Faro, Portugal, 15-16 May, 2009.|
|Abstract(s):||Bacterial cellulose (BC), excreted by Gluconacetobacter xylinus, is a unique nanofibrilar biopolymer with a wide range of applications in human and veterinary medicine, odonthology, pharmaceutical industry, biotechnological, food and paper industry. The major research activities of our research group include the following headlines: - Surface-modification of BC matrices and BC whiskers for the design of novel functional BC nanocomposite systems. This domain includes the surface-activation of BC with CBMs (Carbohydrate Binding Modules) conjugated with bioactive peptides for biomedical applications. CEB-UM has already shown that the adsorption of CBM-RGD (the minimal essential cell adhesion recognition motifs) onto BC improves its ability to adsorb fibroblasts. Also, research on the use of BC tubes as new guides for neuronal growth (CAPES, 3989/05-4) and, for the first time, on assessing the in vivo cytotoxicity of BC nanofibers (SFRH/BD/18418/2004), is on course. - Design of novel BC structures with tailored microporosity, for biomedical applications (SFRH/BD/48759/2008). - Engineering of electro-conductive and electro-active BC scaffolds with potential applications in neuronal growth. The embedded polymeric directionally of the BC nanofibers is expected to exhibit shear piezoelectricity which, coupled with a high in situ moldability, thrusts a promising future for novel BC-based materials such as lightweight, biodegradable electro-actives, biosensors and flexible electric displays, with a tailored oriented stiffness and strength. - Exploring the large-scale fermentation of BC. A novel bioreactor, based on a surfaceculture method was designed. A simple and low-cost piece of equipment is capable of direct nebulization of a high volume of dispersed and microparticulated subtrate over the growing bacteria. The developed system may reveal to be an interesting economic solution for the large-scale production of BC.|
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