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dc.contributor.authorCastanho, Teresa C.por
dc.contributor.authorMoreira, Pedro Miguel Silvapor
dc.contributor.authorNunes, Carlos Portugalpor
dc.contributor.authorNovais, Ashley Cruzpor
dc.contributor.authorCosta, Patrício Soarespor
dc.contributor.authorPalha, Joana Almeidapor
dc.contributor.authorSousa, Nunopor
dc.contributor.authorSantos, Nadine Correiapor
dc.description.abstractAlterations in hormone levels during aging impact on cognition and mood. Serum concentration levels of testosterone (TT), estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), dehydroepiandrosterone sulfate (DHEAS) and prolactin (PRL) were assessed in 120 community-dwellers (51+ years of age, males and females), in a cross-sectional approach. Performance clusters based on executive functioning (GENEXEC), memory (MEM), mood and well-being were obtained. In males, higher PRL levels associated with worse cognitive performance, lower well-being, and higher scores in depression scales, and lower E2 with poorer cognition and higher depressive mood. DHEAS positively associated with GENEXEC and MEM. Nutritional status significantly associated with PRL (positively) and with DHEAS (negatively). Findings indicate that besides the more exhaustively studied E2 and TT, variations in the levels of sex-related hormones such as PRL, FSH, LH and DHEAS are of interest for the mental health aging profile particularly in men.por
dc.description.sponsorshipThe work was funded by the European Commission (FP7): "SwitchBox" project (Contract HEALTH-F2-2010-259772) and co-financed by the Portuguese North Regional Operational Program (ON.2-O Novo Norte) under the National Strategic Reference Framework (QREN), through the European Regional Development Fund (FEDER). NCS is supported by a "SwitchBox" project post-doctoral fellowship, TCC by a Fundacao para a Ciencia e Tecnologia (FCT, Portugal) doctoral fellowship (BD SFRH/BD/90078/2012), PSM and CPN by a "MyHealth" (Contract DoIT-13853) doctoral and research fellowship, respectively.por
dc.publisherElsevier Science BVpor
dc.subjectExecutive functionpor
dc.subjectQuality of lifepor
dc.titleThe role of sex and sex-related hormones in cognition, mood and well-being in older men and womenpor
oaire.citationTitleBiological Psychologypor
dc.subject.wosSocial Sciencespor
dc.subject.wosScience & Technologypor
sdum.journalBiological Psychologypor
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