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TitleThe role of sex and sex-related hormones in cognition, mood and well-being in older men and women
Author(s)Castanho, Teresa C.
Moreira, Pedro Miguel Silva
Nunes, Carlos Portugal
Novais, Ashley Cruz
Costa, Patrício Soares
Palha, Joana Almeida
Sousa, Nuno
Santos, Nadine Correia
KeywordsExecutive function
Quality of life
Issue date2014
PublisherElsevier Science BV
JournalBiological Psychology
Abstract(s)Alterations in hormone levels during aging impact on cognition and mood. Serum concentration levels of testosterone (TT), estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), dehydroepiandrosterone sulfate (DHEAS) and prolactin (PRL) were assessed in 120 community-dwellers (51+ years of age, males and females), in a cross-sectional approach. Performance clusters based on executive functioning (GENEXEC), memory (MEM), mood and well-being were obtained. In males, higher PRL levels associated with worse cognitive performance, lower well-being, and higher scores in depression scales, and lower E2 with poorer cognition and higher depressive mood. DHEAS positively associated with GENEXEC and MEM. Nutritional status significantly associated with PRL (positively) and with DHEAS (negatively). Findings indicate that besides the more exhaustively studied E2 and TT, variations in the levels of sex-related hormones such as PRL, FSH, LH and DHEAS are of interest for the mental health aging profile particularly in men.
Publisher version
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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