Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/32906

TitleHigh-throughput screening for integrative biomaterials design: exploring advances and new trends
Author(s)Oliveira, Mariana B.
Mano, J. F.
KeywordsBiomaterials
High-throughput screening
high-throughput
combinatorial
lab-on-chip testing
arrays
Issue dateOct-2014
PublisherElsevier
JournalTrends in Biotechnology
CitationOliveira M. B., Mano J. F. High-throughput screening for integrative biomaterials design: exploring advances and new trends, Trends in Biotechnology, Vol. 32, Issue 12, pp. 627-636, doi:10.1016/j.tibtech.2014.09.009, 2014
Abstract(s)With the increasing need for biomaterials and tissue engineering alternatives, more accurate, rapid, and cost-saving methods and models to study biomaterial-cell interactions must be developed. We review the evolution of microarray platforms used for such studies in order to meet the criteria of complex tissue engineering biological environments. Particular aspects regarding biomaterials processing, data acquisition, and treatment are addressed. Apart from in vitroarray-based strategies, we also address emerging in vivo high-throughput approaches and their associated trends, such as the role of inflammation in regeneration. The up-scaling of high-throughput methods using single cell encapsulation systems is also explored. Possible limitations related to the use of such methods, such as spot-to-spot crosstalk, are also discussed.
TypeArticle
URIhttp://hdl.handle.net/1822/32906
DOI10.1016/j.tibtech.2014.09.009
ISSN0167-7799
Publisher versionhttp://www.cell.com/trends/biotechnology/abstract/S0167-7799(14)00191-7
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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