Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/32857

TitlePhenoWorld : a new paradigm to screen rodent behavior
Author(s)Castelhano-Carlos, Magda João
Costa, Patrício Soares
Russig, H.
Sousa, Nuno
Issue date2014
PublisherPalgrave Macmillan
JournalTranslational Psychiatry
Abstract(s)Modeling depression in animals has inherent complexities that are augmented by intrinsic difficulties to measure the characteristic features of the disorder. Herein, we describe the PhenoWorld (PhW), a new setting in which groups of six rats lived in an ethological enriched environment, and have their feeding, locomotor activity, sleeping and social behavior automatically monitored. A battery of emotional and cognitive tests was used to characterize the behavioral phenotype of animals living in the PhW and in standard conditions (in groups of six and two rats), after exposure to an unpredictable chronic mild stress paradigm (uCMS) and antidepressants. Data reveal that animals living in the PhW displayed similar, but more striking, behavioral differences when exposed to uCMS, such as increased behavioral despair shown in the forced swimming test, resting/sleep behavior disturbances and reduced social interactions. Moreover, several PhW-cage behaviors, such as spontaneous will to go for food or exercise in running wheels, proved to be sensitive indicators of depressive-like behavior. In summary, this new ethological enriched paradigm adds significant discriminative power to screen depressive-like behavior, in particularly rodent's hedonic behavior.
TypeArticle
URIhttp://hdl.handle.net/1822/32857
DOI10.1038/tp.2014.40
ISSN2158-3188
Publisher versionhttp://www.nature.com
Peer-Reviewedyes
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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