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dc.contributor.authorMartins, Natáliapor
dc.contributor.authorFerreira, Isabel C. F. R.por
dc.contributor.authorBarros, Lillianpor
dc.contributor.authorCarvalho, Ana Mariapor
dc.contributor.authorHenriques, Marianapor
dc.contributor.authorSilva, Sónia Carinapor
dc.identifier.citationMartins, Natália; Ferreira, Isabel C. F. R.; Barros, Lillian; Carvalho, Ana Maria; Henriques, Mariana; Silva, Sónia Carina, Plants used in folk medicine: the potential of their hydromethanolic extracts against Candida species. Industrial Crops and Products, 66, 62-67, 2015.-
dc.description.abstractCurrently, opportunistic fungal infections are considered a serious problem regarding public health. Despite the advances towards the synthesis of new antifungal agents, an increasing incidence of drug-resistant microorganisms has been observed. In this sense, other alternatives are necessary. In the present work, the antifungal activity of extracts from ten different plants, commonly used in folk medicine, were evaluated against nineteen Candida strains, including C. albicans, C. glabrata, C. parapsilosis and C. tropicalis species. Although the majority of the extracts had no antimicrobial effect, Juglans regia extract was very effective, exerting an inhibitory effect against all the tested Candida strains, while Eucalyptus globulus was effective against seventeen of them. Pterospartum tridentatum and Rubus ulmifolius presented similar antifungal effects, being effective against six Candida strains. The diameter of halo ranged, respectively, between 9-14 mm and 9-21 mm to the mentioned plant extracts, and the MIC50 values evidenced mainly a fungistatic activity. Both extracts showed similar MIC50 values for C. albicans strains, while C. parapsilosis and C. glabrata were more sensible to E. globulus. Otherwise, all the C. tropicalis strains were more sensible to J. regia. Overall, hydromethanolic plant extracts could constitute promissory alternatives to the traditional antifungal agents.por
dc.description.sponsorshipThe authors are grateful to Foundation for Science and Technology (FCT, Portugal) for N. Martins grant (SFRH/BD/87658/2012), L. Barros researcher contract under "Programa Compromisso com Ciencia - 2008" and financial support to the research centre CIMO (strategic project PEst-OE/AGR/UI0690/2011). This work was also supported by the Programa Operacional, Fatores de competitividade - COMPETE and by national funds through FCT - Fundacao para a Ciencia e a Tecnologia on the scope of the projects FCT PTDC/SAU-MIC/119069/2010, RECI/EBB-EBI/0179/2012 and PEst-OE/EQB/LA0023/2013. The authors thank the Project "BioHealth - Biotechnology and Bioengineering approaches to improve health quality", Ref. NORTE-07-0124-FEDER-000027, co-funded by the Programa Operacional Regional do Norte (ON.2 - O Novo Norte), QREN, FEDER. The authors are also grateful to "MaisErvas - Aromaticas e Medicinais" and "Americo Duarte Paixao Lda." for the supplying of some plant species.por
dc.subjectMedicinal plantspor
dc.subjectHydromethanolic extractspor
dc.subjectAntifungal activitypor
dc.subjectCandida speciespor
dc.titlePlants used in folk medicine: the potential of their hydromethanolic extracts against Candida speciespor
oaire.citationTitleIndustrial crops and productspor
dc.subject.wosScience & Technologypor
sdum.journalIndustrial crops and productspor
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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