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TitlePlants used in folk medicine: the potential of their hydromethanolic extracts against Candida species
Author(s)Martins, Natália
Ferreira, Isabel C. F. R.
Barros, Lillian
Carvalho, Ana Maria
Henriques, Mariana
Silva, Sónia Carina
KeywordsMedicinal plants
Hydromethanolic extracts
Antifungal activity
Candida species
Issue date2015
JournalIndustrial crops and products
CitationMartins, Natália; Ferreira, Isabel C. F. R.; Barros, Lillian; Carvalho, Ana Maria; Henriques, Mariana; Silva, Sónia Carina, Plants used in folk medicine: the potential of their hydromethanolic extracts against Candida species. Industrial Crops and Products, 66, 62-67, 2015.
Abstract(s)Currently, opportunistic fungal infections are considered a serious problem regarding public health. Despite the advances towards the synthesis of new antifungal agents, an increasing incidence of drug-resistant microorganisms has been observed. In this sense, other alternatives are necessary. In the present work, the antifungal activity of extracts from ten different plants, commonly used in folk medicine, were evaluated against nineteen Candida strains, including C. albicans, C. glabrata, C. parapsilosis and C. tropicalis species. Although the majority of the extracts had no antimicrobial effect, Juglans regia extract was very effective, exerting an inhibitory effect against all the tested Candida strains, while Eucalyptus globulus was effective against seventeen of them. Pterospartum tridentatum and Rubus ulmifolius presented similar antifungal effects, being effective against six Candida strains. The diameter of halo ranged, respectively, between 9-14 mm and 9-21 mm to the mentioned plant extracts, and the MIC50 values evidenced mainly a fungistatic activity. Both extracts showed similar MIC50 values for C. albicans strains, while C. parapsilosis and C. glabrata were more sensible to E. globulus. Otherwise, all the C. tropicalis strains were more sensible to J. regia. Overall, hydromethanolic plant extracts could constitute promissory alternatives to the traditional antifungal agents.
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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