Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/32362

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dc.contributor.authorBessa, J. M.por
dc.contributor.authorPinto, Luisapor
dc.contributor.authorMorais, Mónicapor
dc.contributor.authorSousa, Nunopor
dc.contributor.authorPatrício, P.por
dc.contributor.authorPinheiro, António Mateuspor
dc.contributor.authorAlmeida, Susanapor
dc.contributor.authorFilipe, Augustopor
dc.contributor.authorPedroso, Pedropor
dc.contributor.authorSantos, Paulo A. R.por
dc.date.accessioned2015-01-06T10:24:16Z-
dc.date.available2015-01-06T10:24:16Z-
dc.date.issued2014-12-
dc.identifier.issn1432-2072por
dc.identifier.urihttp://hdl.handle.net/1822/32362-
dc.descriptionOnline first version - Oct 14, 2014por
dc.description.abstractThere is accumulating evidence that adult neurogenesis and dendritic plasticity in the hippocampus are neuroplastic phenomena, highly sensitive to the effects of chronic stress and treatment with most classes of antidepressant drugs, being involved in the onset and recovery from depression. However, the effects of antidepressants that act through the selective inhibition of monoamine oxidase subtype A (MAO-A) in these phenomena are still largely unknown. In the present study, adult neurogenesis and neuronal morphology were examined in the hippocampus of rats exposed to chronic mild stress (CMS) and treated with the selective reversible MAO-A inhibitor (RIMA) drug, pirlindole and the selective serotonin reuptake inhibitor (SSRI), fluoxetine. The results provide the first demonstration that selective MAO-A inhibition with pirlindole is able to revert the behavioural effects of stress exposure while promoting hippocampal adult neurogenesis and rescuing the stress-induced dendritic atrophy of granule neurons.por
dc.description.sponsorshipThis research was funded by a collaborative research project established between ICVS and Grupo Tecnimede.por
dc.language.isoengpor
dc.publisherSAGEpor
dc.rightsopenAccesspor
dc.subjectDepressionpor
dc.subjectPirlindolepor
dc.subjectFluoxetinpor
dc.subjectStresspor
dc.subjectNeuroplasticitypor
dc.subjectHippocampuspor
dc.subjectNeurogenesispor
dc.subjectfluoxetinepor
dc.titleThe effects of chronic stress on hippocampal adult neurogenesis and dendritic plasticity are reversed by selective MAO-A inhibition.por
dc.typearticle-
dc.peerreviewedyespor
dc.relation.publisherversionwww.springer.compor
sdum.publicationstatuspublishedpor
oaire.citationStartPage1178por
oaire.citationEndPage1183por
oaire.citationIssue12por
oaire.citationTitleJournal of Psychopharmacologypor
oaire.citationVolume28por
dc.date.updated2014-12-11T11:33:22Z-
dc.identifier.doi10.1177/0269881114553646por
dc.identifier.pmid25315831por
dc.subject.wosScience & Technologypor
sdum.journalJournal of Psychopharmacologypor
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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