Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/32362

TitleThe effects of chronic stress on hippocampal adult neurogenesis and dendritic plasticity are reversed by selective MAO-A inhibition.
Author(s)Bessa, J. M.
Pinto, Luisa
Morais, Mónica
Sousa, Nuno
Patrício, P.
Pinheiro, António Mateus
Almeida, Susana
Filipe, Augusto
Pedroso, Pedro
Santos, Paulo A. R.
KeywordsDepression
Pirlindole
Fluoxetin
Stress
Neuroplasticity
Hippocampus
Neurogenesis
fluoxetine
Issue dateDec-2014
PublisherSAGE
JournalJournal of Psychopharmacology
Abstract(s)There is accumulating evidence that adult neurogenesis and dendritic plasticity in the hippocampus are neuroplastic phenomena, highly sensitive to the effects of chronic stress and treatment with most classes of antidepressant drugs, being involved in the onset and recovery from depression. However, the effects of antidepressants that act through the selective inhibition of monoamine oxidase subtype A (MAO-A) in these phenomena are still largely unknown. In the present study, adult neurogenesis and neuronal morphology were examined in the hippocampus of rats exposed to chronic mild stress (CMS) and treated with the selective reversible MAO-A inhibitor (RIMA) drug, pirlindole and the selective serotonin reuptake inhibitor (SSRI), fluoxetine. The results provide the first demonstration that selective MAO-A inhibition with pirlindole is able to revert the behavioural effects of stress exposure while promoting hippocampal adult neurogenesis and rescuing the stress-induced dendritic atrophy of granule neurons.
TypeArticle
DescriptionOnline first version - Oct 14, 2014
URIhttp://hdl.handle.net/1822/32362
DOI10.1177/0269881114553646
ISSN1432-2072
Publisher versionwww.springer.com
Peer-Reviewedyes
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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