Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/32361

TítuloDevelopment of an injectable PHBV microparticles-GG hydrogel hybrid system for regenerative medicine
Autor(es)Pacheco, Daniela P.
Amaral, Maria H.
Reis, R. L.
Marques, A. P.
Correlo, V. M.
Palavras-chaveGellan Gum
Injectable hydrogel
Microparticulate systems
Polyhydroxybutyrate-co-hydroxyvalerate
Regenerative medicine
DataJan-2015
EditoraElsevier
RevistaInternational Journal of Pharmaceutics
CitaçãoPacheco D. P., Amaral M. H., Reis R. L., Marques A. P., Correlo V. M. Development of an injectable PHBV microparticles-GG hydrogel hybrid system for regenerative medicine, International Journal of Pharmaceutics, Vol. 478, Issue 1, pp. 398-408, doi:10.1016/j.ijpharm.2014.11.036, 2015
Resumo(s)Uncontrollable displacements that greatly affect the concentration of active agents at the target tissues are among a major limitation of the use of microparticulate drug delivery systems (DDS). Under this context a biphasic injectable DDS combining poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) microparticles (MPs) and a gellan gum (GG) injectable hydrogel is herein proposed for the localized delivery and long-term retention of MPs carrying hydrophilic and hydrophobic model active agents. A double emulsion-solvent evaporation method was adopted to develop the PHBV MPs, carrying bovine serum albumin (BSA) or dexamethasone (Dex) as hydrophilic and hydrophobic active agents’ models, respectively. Moreover, this method was modified, together with the properties of the hydrogel to tailor the delivery profile of the active agents. Variations of the composition of the organic phase during the process allowed tuning surface topography, particle size distribution and core porosity of the PHBV MPs and, thus, the in vitro release profile of Dex but not of BSA. Besides, after embedding hydrogels of higher GG concentration led to a slower and more sustained release of both active agents, independently of the processing conditions of the microparticulate system.
Tipoarticle
URIhttp://hdl.handle.net/1822/32361
DOI10.1016/j.ijpharm.2014.11.036
ISSN0378-5173
Versão da editorahttp://www.sciencedirect.com/science/article/pii/S0378517314008485
Arbitragem científicayes
AcessoopenAccess
Aparece nas coleções:3B’s - Artigos em revistas/Papers in scientific journals

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