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TitleAnticancer effects of lactoferrin: underlying mechanisms and future trends in cancer therapy
Author(s)Zhang, Yunlei
Lima, Cristóvão F.
Rodrigues, L. R.
Anti-cancer activity
Cancer therapy
Issue date18-Jan-2014
PublisherInternational Life Sciences Institute
JournalNutrition Reviews
CitationZhang, Y.; Lima, C. F.; Rodrigues, L. R., Anticancer effects of lactoferrin: underlying mechanisms and future trends in cancer therapy. Nutrition Reviews, 72(12), 763-773, 2014
Abstract(s)Lactoferrin has been widely studied over the last 70 years, and its role in diverse biological functions is now well known and generally accepted by the scientific community. Usually, alterations of the lactoferrin gene in cells are associated with an increased incidence of cancer. Several studies suggest that exogenous treatment with lactoferrin and its derivatives can efficiently inhibit the growth of tumors and reduce susceptibility to cancer. None of these studies, however, reported a consistent outcome with regard to the mechanisms underlying the anticancer effects of lactoferrin. In this review, the association of lactoferrin with cancer is thoroughly discussed, from lactoferrin gene expression to the potential use of lactoferrin in cancer therapy. Lactoferrin cytotoxicity against several cancers is reported to occur in distinct ways under different conditions, namely by cell membrane disruption, apoptosis induction, cell cycle arrest, and cell immunoreaction. Based on these mechanisms, new strategies to improve the anticancer effects of the lactoferrin protein and/or its derivatives are proposed. The potential for lactoferrin in the field of cancer research (including as a chemotherapeutic agent in cancer therapy) is also discussed.
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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