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TitleAntiproliferative Activity of 2,3,6,7-Tetrahydro-1H-benzo[a]quinolizino[1,9-hi]phenoxazin-14(5H)-iminium Chloride Derivatives
Author(s)Leitão, Maria Inês
Raju, B. Rama
Sousa, Maria João
Gonçalves, M. Sameiro T.
Antimicrobial drugs
Nile Blue derivatives
Julolidine derivatives
Issue date2014
PublisherSciforum Electronic Conferences Series
Abstract(s)Compounds based on 1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinolone, trivially designated as julolidine, have been reported due to their biological interest, namely as inhibitors of the amyloid-β protein self-assembly (which is associated to the pathogenesis of Alzheimer’s disease), as well as colorimetric and fluorometric probes. Taking this in account, in addition to the relevant biological importance of benzophenoxazinium salts such as Nile Blue derivatives, the present work evaluated the influence of the julolidine moiety in antimicrobial activity against Saccharomyces cerevisiae PYCC 4072 of newly synthesised fluorescent 2,3,6,7-tetrahydro-1H-benzo[a]quinolizino[1,9-hi]phenoxazin-14(5H)-iminium chlorides, in comparison with their analogues.
TypeConference paper
Publisher version
AccessRestricted access (UMinho)
Appears in Collections:CDQuim - Comunicações e Proceedings

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