Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/31686

Full metadata record
DC FieldValueLanguage
dc.contributor.authorPedrosa, Sílvia Santospor
dc.contributor.authorGonçalves, Catarinapor
dc.contributor.authorDavid, Laurentpor
dc.contributor.authorGama, F. M.por
dc.date.accessioned2014-12-05T15:13:01Z-
dc.date.available2014-12-05T15:13:01Z-
dc.date.issued2014-
dc.identifier.citationPedrosa, S.S.; Gonçalves, Catarina; David, Laurent; Gama, F.M. A novel crosslinked hyaluronic acid nanogel for drug delivery Macromolecular Bioscience 14(11) 1556-1568, 2014.-
dc.identifier.issn1616-5187por
dc.identifier.urihttp://hdl.handle.net/1822/31686-
dc.description.abstractAn amphiphilic hyaluronic acid conjugate is successfully developed based on grafting a thiolated hydrophobic molecule to the polysaccharide backbone. The engineered conjugate is capable of assembling into nanostructures once dispersed in water, with average diameter of 80.2 ± 0.4 nm (n = 5), stable up to 6 months. The thiolated HyA conjugate is reticulated by dissulfide bond with a homofunctional crosslinker—1,4-Bis(3-[2-pyridyldithio]propionamido)butane (DPDPB). The drug loading efficiency of the reticulated and non-reticulated nanogel is accessed with two hydrophobic drugs, curcumin and simvastatin. Results suggest that crosslinked nanogel exhibit higher stability upon dilution and drug loading efficiency and proves to be a redox sensitive material. The nanogels hold great potential as stealth carriers of lipophilic drugs.por
dc.description.sponsorshipThe authors would like to acknowledge the support of FCT for the PhD grant reference SFRH/BD/61516/2009.por
dc.language.isoengpor
dc.publisherJohn Wiley and Sonspor
dc.rightsopenAccesspor
dc.titleA novel crosslinked hyaluronic Acid nanogel for drug deliverypor
dc.typearticle-
dc.peerreviewedyespor
dc.commentsCEB18037por
sdum.publicationstatuspublishedpor
oaire.citationStartPage1556por
oaire.citationEndPage1568por
oaire.citationIssue11por
oaire.citationConferencePlaceUnited Kingdom-
oaire.citationTitleMacromolecular biosciencepor
oaire.citationVolume14por
dc.date.updated2014-11-28T17:46:33Z-
dc.identifier.essn1616-5195-
dc.identifier.doi10.1002/mabi.201400135por
dc.identifier.pmid25088667por
dc.subject.wosScience & Technologypor
sdum.journalMacromolecular biosciencepor
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

Files in This Item:
File Description SizeFormat 
document_18037_1.pdf1,39 MBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID