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|Title:||A novel crosslinked hyaluronic Acid nanogel for drug delivery|
|Author(s):||Pedrosa, Sílvia Santos|
Gama, F. M.
|Publisher:||John Wiley and Sons|
|Citation:||Pedrosa, S.S.; Gonçalves, Catarina; David, Laurent; Gama, F.M. A novel crosslinked hyaluronic acid nanogel for drug delivery Macromolecular Bioscience 14(11) 1556-1568, 2014.|
|Abstract(s):||An amphiphilic hyaluronic acid conjugate is successfully developed based on grafting a thiolated hydrophobic molecule to the polysaccharide backbone. The engineered conjugate is capable of assembling into nanostructures once dispersed in water, with average diameter of 80.2 ± 0.4 nm (n = 5), stable up to 6 months. The thiolated HyA conjugate is reticulated by dissulfide bond with a homofunctional crosslinker—1,4-Bis(3-[2-pyridyldithio]propionamido)butane (DPDPB). The drug loading efficiency of the reticulated and non-reticulated nanogel is accessed with two hydrophobic drugs, curcumin and simvastatin. Results suggest that crosslinked nanogel exhibit higher stability upon dilution and drug loading efficiency and proves to be a redox sensitive material. The nanogels hold great potential as stealth carriers of lipophilic drugs.|
|Appears in Collections:||CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series|