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TitleA novel crosslinked hyaluronic Acid nanogel for drug delivery
Author(s)Pedrosa, Sílvia Santos
Gonçalves, Catarina
David, Laurent
Gama, F. M.
Issue date2014
PublisherJohn Wiley and Sons
JournalMacromolecular bioscience
CitationPedrosa, S.S.; Gonçalves, Catarina; David, Laurent; Gama, F.M. A novel crosslinked hyaluronic acid nanogel for drug delivery Macromolecular Bioscience 14(11) 1556-1568, 2014.
Abstract(s)An amphiphilic hyaluronic acid conjugate is successfully developed based on grafting a thiolated hydrophobic molecule to the polysaccharide backbone. The engineered conjugate is capable of assembling into nanostructures once dispersed in water, with average diameter of 80.2 ± 0.4 nm (n = 5), stable up to 6 months. The thiolated HyA conjugate is reticulated by dissulfide bond with a homofunctional crosslinker—1,4-Bis(3-[2-pyridyldithio]propionamido)butane (DPDPB). The drug loading efficiency of the reticulated and non-reticulated nanogel is accessed with two hydrophobic drugs, curcumin and simvastatin. Results suggest that crosslinked nanogel exhibit higher stability upon dilution and drug loading efficiency and proves to be a redox sensitive material. The nanogels hold great potential as stealth carriers of lipophilic drugs.
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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