Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/31686

TitleA novel crosslinked hyaluronic Acid nanogel for drug delivery
Author(s)Pedrosa, Sílvia Santos
Gonçalves, Catarina
David, Laurent
Gama, F. M.
Issue date2014
PublisherJohn Wiley and Sons
JournalMacromolecular bioscience
CitationPedrosa, S.S.; Gonçalves, Catarina; David, Laurent; Gama, F.M. A novel crosslinked hyaluronic acid nanogel for drug delivery Macromolecular Bioscience 14(11) 1556-1568, 2014.
Abstract(s)An amphiphilic hyaluronic acid conjugate is successfully developed based on grafting a thiolated hydrophobic molecule to the polysaccharide backbone. The engineered conjugate is capable of assembling into nanostructures once dispersed in water, with average diameter of 80.2 ± 0.4 nm (n = 5), stable up to 6 months. The thiolated HyA conjugate is reticulated by dissulfide bond with a homofunctional crosslinker—1,4-Bis(3-[2-pyridyldithio]propionamido)butane (DPDPB). The drug loading efficiency of the reticulated and non-reticulated nanogel is accessed with two hydrophobic drugs, curcumin and simvastatin. Results suggest that crosslinked nanogel exhibit higher stability upon dilution and drug loading efficiency and proves to be a redox sensitive material. The nanogels hold great potential as stealth carriers of lipophilic drugs.
TypeArticle
URIhttp://hdl.handle.net/1822/31686
DOI10.1002/mabi.201400135
ISSN1616-5187
e-ISSN1616-5195
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

Files in This Item:
File Description SizeFormat 
document_18037_1.pdf1,39 MBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID