Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/31682

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dc.contributor.authorFernandes, J. G.por
dc.contributor.authorCorreia, D. M.por
dc.contributor.authorBotelho, Gabrielapor
dc.contributor.authorPadrão, Jorgepor
dc.contributor.authorDourado, Fernandopor
dc.contributor.authorRibeiro, C.por
dc.contributor.authorLanceros-Méndez, S.por
dc.contributor.authorSencadas, Vítor João Gomes Silvapor
dc.date.accessioned2014-12-05T14:52:54Z-
dc.date.available2014-12-05T14:52:54Z-
dc.date.issued2014-
dc.identifier.citationFernandes, J. G.; Correia, D. M.; Botelho, G.; Padrão, J.; Dourado, Fernando; Ribeiro, C.; Lanceros-Méndez, S.; Sencadas, V., PHB-PEO electrospun fiber membranes containing chlorhexidine for drug delivery applications. Polymer Testing, 34, 64-71, 2014por
dc.identifier.issn0142-9418por
dc.identifier.urihttp://hdl.handle.net/1822/31682-
dc.description.abstractFiber meshes of poly(hydroxybutyrate) (PHB) and poly(hydroxybutyrate)/poly(ethylene oxide) (PHB/PEO) with different concentrations of chlorhexidine (CHX) were prepared by electrospinning for assessment as a polymer based drug delivery system. The electrospun fibers were characterized at morphological, molecular and mechanical levels. The bactericidal potential of PHB and PHB/PEO electrospun fibers, with and without CHX, was investigated against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) by disk diffusion susceptibility tests. Electrospun fibers containing CHX exhibited bactericidal activity. PHB/PEO-1%CHX displayed higher CHX release levels and equivalent antibacterial activity when compared to PHB/PEO with 5 and 10 wt% CHX. Bactericidal performance of samples with 1 wt% CHX was assessed by Colony Forming Units (CFU), where reductions of 100% and 99.69% against E. coli and S. aureus were achieved, respectively.por
dc.description.sponsorshipThis work was supported by FEDER through the COMPETE Program and by the Portuguese Foundation for Science and Technology (FCT) in the framework of the Strategic Project PEST-C/FIS/UI607/2011 and PEST-C/QUI/UIO686/2011. The authors also thank funding from Matepro - Optimizing Materials and Processes", ref. NORTE-07-0124-FEDER-000037", co-funded by the "Programa Operacional Regional do Norte" (ON.2 - O Novo Norte), under the "Quadro de Referencia Estrategico Nacional" (QREN), through the "Fundo Europeu de Desenvolvimento Regional" (FEDER). D.M.C, JP and VS thanks the FCT for the, SFRH/BD/82411/2011, SFRH/BD/64901/2009 and SFRH/BPD/63148/2009 grants respectively. The authors also thank support from the COST Action MP1003, 2010 'European Scientific Network for Artificial Muscles' and to the COST Action MP1206 'Electrospun Nano-fibres for Bio inspired Composite Materials and Innovative Industrial Applications'. The authors also thank prof. Jose Luis Gomez Ribelles from the Unversidad Politecnica de Valencia, Spain, for interesting discussions on these issues.por
dc.language.isoengpor
dc.publisherElsevier B.V.por
dc.rightsopenAccesspor
dc.subjectElectrospun fiberspor
dc.subjectDrug release kineticspor
dc.subjectAntibacterial activitypor
dc.subjectBiopolymerspor
dc.subjectChlorhexidinepor
dc.titlePHB-PEO electrospun fiber membranes containing chlorhexidine for drug delivery applicationspor
dc.typearticle-
dc.peerreviewedyespor
dc.commentsCEB18100por
sdum.publicationstatuspublishedpor
oaire.citationStartPage64por
oaire.citationEndPage71por
oaire.citationConferencePlaceNetherlands-
oaire.citationTitlePolymer Testingpor
oaire.citationVolume34por
dc.date.updated2014-11-28T17:44:35Z-
dc.identifier.essn0142-9418-
dc.identifier.doi10.1016/j.polymertesting.2013.12.007por
dc.subject.wosScience & Technologypor
sdum.journalPolymer Testingpor
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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