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TitleAssembling human Platelet Lysate into multiscale 3D scaffolds for bone tissue engineering
Author(s)Oliveira, Sara M.
Reis, R. L.
Mano, J. F.
Platelet Lysate
Sulfated polysaccharides
layer-by-layer assembling
multiscale scaffold
Issue date2015
JournalACS Biomaterials Science and Engineering
CitationOliveira S. M., Reis R. L., Mano J. F. Assembling human Platelet Lysate into Multiscale 3D Scaffolds for Bone Tissue Engineering, ACS Biomaterials Science & Engineering, Vol. 1, Issue 1, DOI: 10.1021/ab500006x, 2015.
Abstract(s)Scaffolds for bone tissue engineering lack often control of cellular instructions. We propose a triple sequential approach for customizing scaffold features from the macro to the nanoscale. The nano/meso-scale is composed by human platelet lysate and marine-origin polysaccharides assembled by layer-by-layer and shaped into fibrils by freeze-drying. We show that osteogenic induction of stem cells is tunable within a low range of layers. This approach has the potential to develop new scaffolds with enhanced cell-instructive capabilities using affordable autologous sources of bioactive molecules.
Publisher version
AccessRestricted access (UMinho)
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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