Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/31545

TitleAssembling human Platelet Lysate into multiscale 3D scaffolds for bone tissue engineering
Author(s)Oliveira, Sara M.
Reis, R. L.
Mano, J. F.
KeywordsBone
Carrageenan
Layer-by-layer
Multiscale
Platelet Lysate
Sulfated polysaccharides
layer-by-layer assembling
osteogenesis
multiscale scaffold
instructive
Issue date2015
PublisherACS
JournalACS Biomaterials Science and Engineering
CitationOliveira S. M., Reis R. L., Mano J. F. Assembling human Platelet Lysate into Multiscale 3D Scaffolds for Bone Tissue Engineering, ACS Biomaterials Science & Engineering, Vol. 1, Issue 1, DOI: 10.1021/ab500006x, 2015.
Abstract(s)Scaffolds for bone tissue engineering lack often control of cellular instructions. We propose a triple sequential approach for customizing scaffold features from the macro to the nanoscale. The nano/meso-scale is composed by human platelet lysate and marine-origin polysaccharides assembled by layer-by-layer and shaped into fibrils by freeze-drying. We show that osteogenic induction of stem cells is tunable within a low range of layers. This approach has the potential to develop new scaffolds with enhanced cell-instructive capabilities using affordable autologous sources of bioactive molecules.
TypeArticle
URIhttp://hdl.handle.net/1822/31545
DOI10.1021/ab500006x
ISSN2373-9878
Publisher versionhttp://pubs.acs.org/doi/abs/10.1021/ab500006x
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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