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|Title:||Assembling human Platelet Lysate into multiscale 3D scaffolds for bone tissue engineering|
|Author(s):||Oliveira, Sara M.|
Reis, R. L.
Mano, J. F.
|Journal:||ACS Biomaterials Science and Engineering|
|Citation:||Oliveira S. M., Reis R. L., Mano J. F. Assembling human Platelet Lysate into Multiscale 3D Scaffolds for Bone Tissue Engineering, ACS Biomaterials Science & Engineering, Vol. 1, Issue 1, DOI: 10.1021/ab500006x, 2015.|
|Abstract(s):||Scaffolds for bone tissue engineering lack often control of cellular instructions. We propose a triple sequential approach for customizing scaffold features from the macro to the nanoscale. The nano/meso-scale is composed by human platelet lysate and marine-origin polysaccharides assembled by layer-by-layer and shaped into fibrils by freeze-drying. We show that osteogenic induction of stem cells is tunable within a low range of layers. This approach has the potential to develop new scaffolds with enhanced cell-instructive capabilities using affordable autologous sources of bioactive molecules.|
|Access:||Restricted access (UMinho)|
|Appears in Collections:||3B’s - Artigos em revistas/Papers in scientific journals|
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