Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/31493

TítuloSynthesis, characterisation and antifungal activity of chemically and fungal-produced silver nanoparticles against Trichophyton rubrum
Autor(es)Pereira, Leonel
Dias, Nicolina
Carvalho, Juliana
Fernandes, Sara
Santos, Cledir
Lima, Nelson
Palavras-chaveAntimicrobials
Fungi
Infection
Mycology
Dermatophytes
Data1-Jan-2014
EditoraBlackwell Publishing Inc.
RevistaJournal of Applied Microbiology
CitaçãoPereira, Leonel; Dias, Nicolina; Carvalho, J.; Fernandes, Sara; Santos, C.; Lima, Nelson, Synthesis, characterization and antifungal activity of chemically and fungal-produced silver nanoparticles against Trichophyton rubrum. Journal of Applied Microbiology, 117(6), 1601-1613, 2014
Resumo(s)Aims To characterise and explore the potential in extracellular biosynthesis of silver nanoparticles (AgNPs) by Penicillium chrysogenum and Aspergillus oryzae and to investigate the antifungal effect of chemically vs. biologically synthesised AgNPs comparing with conventional antifungal drugs against Trichophyton rubrum. Methods and Results Chemically synthesised AgNPs (Chem-AgNPs) coated with polyvinylpyrrolidone (PVP) were synthesised by chemical reduction method with glucose in PVP aqueous solution. Biologically synthesised AgNPs (Bio-AgNPs) were produced from the extracellular cell-free filtrate of Penicillium chrysogenum MUM 03.22 and Aspergillus oryzae MUM 97.19. Among the commercial antifungal drugs terbinafine exhibited the lower MIC range values of 0.063 to 0.25 μg ml-1 for the clinical strains. Chem-AgNPs exhibited antifungal activity against all T. rubrum strains. Bio-AgNPs produced by the fungal cell-free filtrate of P. chrysogenum showed an antifungal activity higher than fluconazole but less than terbinafine, itraconazole and Chem-AgNPs. Conclusion The synthesis parameters in future works should be carefully studied to take full advantage of all the potential of filamentous fungi in the synthesis of AgNPs. Significance and Impact of the study: Bio-AgNPs could be used as antifungal agents, namely against dermatophytes
Tipoarticle
URIhttp://hdl.handle.net/1822/31493
DOI10.1111/jam.12652
ISSN1364-5072
e-ISSN1365-2672
Arbitragem científicayes
AcessoopenAccess
Aparece nas coleções:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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