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dc.contributor.authorSárria, M. P.por
dc.contributor.authorNogueira, Eugéniapor
dc.contributor.authorOliveira, A.por
dc.contributor.authorMatamá, Maria Teresapor
dc.contributor.authorGuimarães, Diana Isabel Pereirapor
dc.contributor.authorBorges, C.por
dc.contributor.authorPaulo, Artur Cavacopor
dc.contributor.authorGomes, A. C.-
dc.identifier.citationSárria, M. P.; Nogueira, Eugénia; Oliveira, A.; Matamá, Maria Teresa; Borges, Cidália; Paulo, Artur Cavaco; Gomes, A. C., Delivery of cytarabine by pegylated liposomes for efficient, long-term anticancer effects. IPFB2014 - 8th International Conference on Polymer and Fiber Biotechnology. Braga, Portugal, May 25-27, 2014.-
dc.description.abstractThe cytosine arabinoside cytarabine is an effective marine-derived antineoplastic agent for the treatment of acute myelogrnous and lymphocytic leukemias. As this nucleoside antimetabolite is an S-phase-specific drug, prolonged exposure of cells to toxic concentrations is critical to achieve maximum biological effect. The activity of cytarabine is nevertheless decreased by its rapid deamination to the biologically inactive metabolite uracil arabinoside. This rapid degradation process is the reason for the ongoing search for efficient formulations and derivatives of cytarabine that cannot be deaminated and exhibited better pharmacokinetic parameters. In the present study, pegylated liposomes were modified for intended prolonged delivery of cytarabine and tested for improved cytotoxic and cytostatic effect in different human cancer lines.por
dc.publisherUniversidade do Minho. Departamento de Engenharia Biológica (DEB)por
dc.titleDelivery of cytarabine by pegylated liposomes for efficient, long-term anticancer effectspor
oaire.citationConferenceDate25 - 27 Maio 2014por
oaire.citationConferencePlaceBraga, Portugalpor
oaire.citationTitleIPFB2014 - 8th International Conference on Polymer and Fiber Biotechnologypor
Appears in Collections:CEB - Resumos em Livros de Atas / Abstracts in Proceedings

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