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TitleDelivery of cytarabine by pegylated liposomes for efficient, long-term anticancer effects
Author(s)Sárria, M. P.
Nogueira, Eugénia
Oliveira, A.
Matamá, Maria Teresa
Guimarães, Diana Isabel Pereira
Borges, C.
Paulo, Artur Cavaco
Gomes, A. C.
Issue date2014
PublisherUniversidade do Minho. Departamento de Engenharia Biológica (DEB)
CitationSárria, M. P.; Nogueira, Eugénia; Oliveira, A.; Matamá, Maria Teresa; Borges, Cidália; Paulo, Artur Cavaco; Gomes, A. C., Delivery of cytarabine by pegylated liposomes for efficient, long-term anticancer effects. IPFB2014 - 8th International Conference on Polymer and Fiber Biotechnology. Braga, Portugal, May 25-27, 2014.
Abstract(s)The cytosine arabinoside cytarabine is an effective marine-derived antineoplastic agent for the treatment of acute myelogrnous and lymphocytic leukemias. As this nucleoside antimetabolite is an S-phase-specific drug, prolonged exposure of cells to toxic concentrations is critical to achieve maximum biological effect. The activity of cytarabine is nevertheless decreased by its rapid deamination to the biologically inactive metabolite uracil arabinoside. This rapid degradation process is the reason for the ongoing search for efficient formulations and derivatives of cytarabine that cannot be deaminated and exhibited better pharmacokinetic parameters. In the present study, pegylated liposomes were modified for intended prolonged delivery of cytarabine and tested for improved cytotoxic and cytostatic effect in different human cancer lines.
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AccessOpen access
Appears in Collections:CEB - Resumos em Livros de Atas / Abstracts in Proceedings

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