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dc.contributor.authorVasconcelos, Mayron Alvespor
dc.contributor.authorArruda, Francisco Vassiliepe Sousapor
dc.contributor.authorAlencar, Daniel Barroso depor
dc.contributor.authorSampaio, Silvana Sakerpor
dc.contributor.authorAlbuquerque, Maria Rose Jane Ribeiropor
dc.contributor.authorSantos, Hélcio Silva dospor
dc.contributor.authorBandeira, Paulo Nogueirapor
dc.contributor.authorPessoa, Otília Deusdênio Loiolapor
dc.contributor.authorCavada, Benildo Sousapor
dc.contributor.authorHenriques, Marianapor
dc.contributor.authorPereira, Maria Olíviapor
dc.contributor.authorTeixeira, Edson Holandapor
dc.description.abstractThis study evaluated the effect of derriobtusone A, a flavonoid isolated from Lonchocarpus obtusus, on two important pathogenic bacteria, Staphylococcus aureus and Escherichia coli, as well as its antioxidant activity and toxicity. Planktonic growth assays were performed, and the inhibition of biofilm formation was evaluated. In addition, antioxidant activity was assessed by DPPH radical scavenging assay, ferrous ion chelating assay, ferric-reducing antioxidant power assay, and β-carotene bleaching assay. Toxicity was evaluated by the brine shrimp lethality test. Results showed that derriobtusone A completely inhibited the planktonic growth of S. aureus at 250 and 500 μg/mL; however, it did not have the same activity on E. coli. Derriobtusone A reduced the biomass and colony-forming unit (cfu) of S. aureus biofilm at concentrations of 250 and 500 μg/mL. In various concentrations, it reduced the biofilm biomass of E. coli, and, in all concentrations, it weakly reduced the cfu. Derriobtusone A showed highly efficient antioxidant ability in scavenging DPPH radical and inhibiting β-carotene oxidation. The compound showed no lethality to Artemia sp. nauplii. In conclusion, derriobtusone A may be an effective molecule against S. aureus and its biofilm, as well as a potential antioxidant compound with no toxicity.por
dc.description.sponsorshipThis study was supported by CAPES (Brazil) through the BEX NT 2052/11NT3 Project and by IBB-CEB and FCT (Portugal) and European Community Fund FEDER, through Program COMPETE, in the ambit of Project PTDC/SAU-ESA/646091/2006/FCOMP-01-0124-FEDER-007480. Otilia Deusdenia Loiola Pessoa, Benildo Sousa Cavada, and Edson Holanda Teixeira are Senior Fellows of CNPq. Mr. David Martin helped with the English editing of the paper.por
dc.publisherHindawi Publishing Corporationpor
dc.titleAntibacterial and antioxidant activities of Derriobtusone A isolated from Lonchocarpus obtususpor
oaire.citationTitleBioMed Research Internationalpor
dc.subject.wosScience & Technologypor
sdum.journalBiomed Research Internationalpor
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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